DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL5 and dbo

DIOPT Version :9

Sequence 1:	XP_011512001.1	Gene:	KLHL5 / 51088	HGNCID:	6356	Length:	804	Species:	Homo sapiens
Sequence 2:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	250/597 - (41%)
Similarity:	376/597 - (62%)	Gaps:	54/597 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   182 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMEN 246
            |:..:|||              .|..|.|::|:                    .|.:.|..::..
  Fly    34 GSTAVDRP--------------PSPARLSHTSE--------------------KHPKVTLTELNM 64

Human   247 YLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQY 311
            ..||::||||:|..|.|:|.|||::||:.|.||.||||.::.|:||.|:.:..::.|::..||.:
  Fly    65 LRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDF 129

Human   312 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAH 376
            .||..:.::|.|::.||..||||||.::.:.||:||.:||.|:||||||:|||...|.:|.::|.
  Fly   130 CYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIAD 194

Human   377 NYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLA 441
            .:|..:|.||:.::||:|||..::..::.||::|:.:||.:.||:::|:::::.:||:.|:::|.
  Fly   195 KFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQ 259

Human   442 YIRLPLLAPQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST--VGTL 503
            ::|||||:|:|| ..:.:::|.|.|..|:.|:.||..|.|||:.||::|.|||:|||.|  ...|
  Fly   260 HVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVL 324

Human   504 FAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 568
            |||||..|.....|:|::|.:||.|..||.|:.||...|||||:|.||.|||.||...||::|.|
  Fly   325 FAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERY 389

Human   569 NPKTKTWSV-MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPR 632
            :|:|..||. :.|.::.|..:|||||:|.:|||||.||...||.|||:||:..:|:.||.|:|.|
  Fly   390 DPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRR 454

Human   633 STVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH 697
            ..|.||||.|.|||:||.||...|.:||.:||..|||...:.||.||..:|...:|..:||:||.
  Fly   455 LGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGR 519

Human   698 DAPASNLTSRLSDCV-----ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLN 757
            |           ||:     |||:|.|:.|:.:.:|:..|..||:.::..:||||||:||.|||.
  Fly   520 D-----------DCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLK 573

Human   758 TVEAYDPQTNEW 769
            |:|.|||:||:|
  Fly   574 TIEVYDPETNQW 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL5	XP_011512001.1	BTB	244..347	CDD:279045	43/102 (42%)
		PHA03098	254..775	CDD:222983	237/525 (45%)
		BACK	356..455	CDD:285009	40/99 (40%)
		Kelch	503..548	CDD:128874	23/44 (52%)
		Kelch_1	537..582	CDD:279660	24/45 (53%)
		KELCH repeat	538..581	CDD:276965	22/43 (51%)
		KELCH repeat	585..629	CDD:276965	24/43 (56%)
		Kelch	598..642	CDD:128874	25/43 (58%)
		KELCH repeat	632..675	CDD:276965	22/42 (52%)
		Kelch	643..689	CDD:128874	20/45 (44%)
		Kelch_1	678..729	CDD:279660	17/55 (31%)
		KELCH repeat	679..729	CDD:276965	16/54 (30%)
		Kelch_1	732..772	CDD:279660	22/38 (58%)
		KELCH repeat	732..772	CDD:276965	22/38 (58%)
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	53/146 (36%)
		PHA03098	69..587	CDD:222983	238/528 (45%)
		KELCH repeat	359..403	CDD:276965	22/43 (51%)
		KELCH repeat	407..451	CDD:276965	24/43 (56%)
		KELCH repeat	454..497	CDD:276965	22/42 (52%)
		KELCH repeat	501..545	CDD:276965	16/54 (30%)
		KELCH repeat	548..593	CDD:276965	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820