Protein Alignment YARS2 and MSY1

DIOPT Version :10

• Sequence 1: NP_001035526.1
• Gene: YARS2 / 51067
• HGNCID: 24249
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_015228.1
• Gene: MSY1 / 856007
• SGDID: S000006018
• Length: 492
• Species: Saccharomyces cerevisiae
• Alignment Length: 458
• Identity: 156/458 - (34%)
• Similarity: 258/458 - (56%)
• Gaps: 35/458 - (7%)

Human    33 SGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTI--YCGFDPTADSLHVGHLLAL 95
            |.:..:|...|.|||.        :::..||.|.|...:....|  |||.||||.|||:|:|:.|
Yeast    51 SRSDNILDELKQRGLV--------SQVSQPESFLRTKLNGNDKIKLYCGVDPTAQSLHLGNLVPL 107

Human    96 LGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLF- 159
            :.|.|....||:::.::||||.::||||||..||:.:|.:..::|..::...|:....|..:.:
Yeast   108 MVLLHFYVKGHDIVTVIGGATGKVGDPSGRKTERDVMENDIRQSNVASISQQLQRFFKNGLEYYR 172

Human   160 -----TDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEF 219
                 |:....|.:|..:|..|::...::||||..|.|.|:.::|:|.|:..||::..|:...||
Yeast   173 NRCALTEDVPSGKYTPRNNFNWWKDIKMLDFLADFGRHIRVQSMLARDSISSRLQTKNGLGFNEF 237

Human   220 FYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDV------FGITVPLITSTT 278
            .||||||||||:|::.....:|:||:||.|||.:|.:.||::  :.:      |||||||:|:.|
Yeast   238 TYQVLQAYDFYHLYKEENVTIQVGGNDQWGNITAGIDLINRI--QPIKNKGLPFGITVPLLTTAT 300

Human   279 GAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERR 343
            |.|.||||||||:::....:.:::||||....|..|.::||:||||...||..|::.|:|.|..|
Yeast   301 GEKFGKSAGNAVFIDPSINTAYDVYQFFYNTLDADVPKFLKIFTFLNSSEIKKIVETHIKSPSLR 365

Human   344 GPQKRLAAEVTKLVHG-REGLDSAKRCTQALYHSSIDALE-VMSDQELKELFKEAPFSEFFLDPG 406
            ..|..||.|||.:::| ..|.||     :||.:......: .:|..:|.:|.|:|...: :.|..
Yeast   366 YGQTLLAKEVTDMLYGVGSGSDS-----EALSNIIFGRYDGTLSAAKLVDLCKKARILQ-YADRE 424

Human   407 TSVLD-TCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFY 470
            ..::. .|:..|......|  |.:::|.|.::|.:....|::..:...::.:.:.:|:|||:..:
Yeast   425 IDLIKLICKLVNCSVSEAR--RKLSQGSVYLHHSKSKVNENISNLAPFLIDDRVLILRIGKQKCF 487

Human   471 IIK 473
            ||:
Yeast   488 IIE 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YARS2	NP_001035526.1	TyrS	38..474	CDD:439932	155/453 (34%)
		'HIGH' region. /evidence=ECO:0000305	82..91		6/8 (75%)
		'KMSKS' region. /evidence=ECO:0000305	281..285		2/3 (67%)
MSY1	NP_015228.1	tyrS	54..471	CDD:272976	149/434 (34%)