Protein Alignment PCK2 and Pepck2

DIOPT Version :10

• Sequence 1: NP_004554.3
• Gene: PCK2 / 5106
• HGNCID: 8725
• Length: 640
• Species: Homo sapiens
• Sequence 2: NP_611341.1
• Gene: Pepck2 / 37130
• FlyBaseID: FBgn0034356
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 407/618 - (65%)
• Similarity: 471/618 - (76%)
• Gaps: 10/618 - (1%)

Human    29 TLRVLS---GDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYN 90
            |.|.||   ||...|...::.:||....|||||.:|||||||.|:.....::.::|.|..||||.
  Fly    25 TCRFLSIQYGDAKILTPAVKQYVEKCVELCQPERVHICDGTEVESKLLQGIMLKKGTIIPLPKYE 89

Human    91 NCWLARTDPKDVARVESKTVIVTPSQRDTVPLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGR 155
            |||||||:|.||||||.||.|.|.|:..|||:......|.||||::..|.|.|:.|||||||:||
  Fly    90 NCWLARTNPADVARVEGKTFISTDSKEQTVPVTEKATPGMLGNWIAEKDMQAAIKERFPGCMKGR 154

Human   156 TMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQAL--GDGDFVKCLHSVGQPL 218
            ||||:||||||||||||:||:::|||.|||.||:||||.|.|||..|  |||.|||||||||.|.
  Fly   155 TMYVIPFSMGPVGSPLSKIGIEITDSPYVVESMKIMTRAGNPVLNYLQSGDGQFVKCLHSVGTPK 219

Human   219 TG-QGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEH 282
            :| |..|  .|||:||:|::.|.|.:.||:|:||||||||||||||.||||.|.:|:.|||||||
  Fly   220 SGVQAMP--SWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLALRIGSTIAKREGWLAEH 282

Human   283 MLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPE 347
            |||||||:|.|||.|:||||||||||||||||.|.|||:||||||||||||:||::|.|||||||
  Fly   283 MLILGITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWMKFDNKGVLRAINPE 347

Human   348 NGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPG 412
            |||||||||||..|||.||.||..|::|||||.||||||||||:::....|||||.||||.|...
  Fly   348 NGFFGVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQLKGVTVTDWLGKLWSQE 412

Human   413 DKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSA 477
            ..:|.||||||||.||.||||:|||||..|||||.||:||||||.||||||||.:|:||||:|:|
  Fly   413 SGKPAAHPNSRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPLVYEARDWKHGVFIGAA 477

Human   478 MRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGH 542
            ||||:|||||.|||:|||||||||||||||||.||.||||||.|  .|:|:||||||||:...|.
  Fly   478 MRSEATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQR--GQVPKIFHVNWFRKSSEGK 540

Human   543 FLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEV 607
            |||||||||:||||||.||:|||....::|||.:|.:.:|:|..|..||..|||.||||||||||
  Fly   541 FLWPGFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKNSLNLDSLENIDLDQLFDLPKDFWEQEV 605

Human   608 RDIRSYLTEQVNQDLPKEVLAELEALERRVHKM 640
            ..|..|..|||...||..|..||..|:.||..|
  Fly   606 AAIERYFEEQVGHHLPGAVAEELRELKARVADM 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCK2	NP_004554.3	PEPCK_GTP	44..633	CDD:238417	396/591 (67%)
Pepck2	NP_611341.1	PEPCK_GTP	43..631	CDD:238417	396/591 (67%)