Protein Alignment EXOSC3 and RRP40

DIOPT Version :10

• Sequence 1: NP_057126.2
• Gene: EXOSC3 / 51010
• HGNCID: 17944
• Length: 275
• Species: Homo sapiens
• Sequence 2: NP_014499.2
• Gene: RRP40 / 854023
• SGDID: S000005502
• Length: 240
• Species: Saccharomyces cerevisiae
• Alignment Length: 249
• Identity: 77/249 - (30%)
• Similarity: 118/249 - (47%)
• Gaps: 29/249 - (11%)

Human    28 VLPGEELLL-PEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEP 91
            :.||:...: |......|||                  :.|.|..:    .:.....|.| |...
Yeast     5 IFPGDSFPVDPTTPVKLGPG------------------IYCDPNTQ----EIRPVNTGVL-HVSA 46

Human    92 GSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGG-SEPASLSYLSFEGATKRNRP 155
            ...||....::|...|||:|...|.|||::.....|.:||.:.. |...||||::|..|:|:|||
Yeast    47 KGKSGVQTAYIDYSSKRYIPSVNDFVIGVIIGTFSDSYKVSLQNFSSSVSLSYMAFPNASKKNRP 111

Human   156 NVQVGDLIYGQFVVANKDMEPEMVCIDS-CGRANGMGVIGQDGLLFKVTLGLIRKLL-APDCEII 218
            .:|||||:|.:...|.|::|.|:.|.|| .||..|.|:: :||::..|.|...|:|| ..|..::
Yeast   112 TLQVGDLVYARVCTAEKELEAEIECFDSTTGRDAGFGIL-EDGMIIDVNLNFARQLLFNNDFPLL 175

Human   219 QEVGKLYPLEIVFGMNGRIWVKAKTIQQTL-ILANILEACEHMTSDQRKQIFSR 271
            :.:......|:..|:||:||||.:.:..|| ....|:|.|:...:...|.|..|
Yeast   176 KVLAAHTKFEVAIGLNGKIWVKCEELSNTLACYRTIMECCQKNDTAAFKDIAKR 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EXOSC3	NP_057126.2	S1_Rrp40	108..193	CDD:240216	38/86 (44%)
		KH-I_Rrp40	196..273	CDD:411954	24/78 (31%)
RRP40	NP_014499.2	Rrp40_N	12..63	CDD:436400	12/73 (16%)
		S1_Rrp40	63..150	CDD:240216	38/86 (44%)
		KH-I_Rrp40	152..231	CDD:411954	24/78 (31%)