DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PCDH9 and cdh-8

DIOPT Version :10

Sequence 1:NP_982354.1 Gene:PCDH9 / 5101 HGNCID:8661 Length:1237 Species:Homo sapiens
Sequence 2:NP_001294412.1 Gene:cdh-8 / 184652 WormBaseID:WBGene00017576 Length:1684 Species:Caenorhabditis elegans


Alignment Length:1246 Identity:295/1246 - (23%)
Similarity:475/1246 - (38%) Gaps:290/1246 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     6 FYLLAALIACLR-LDSA--IAQELIYTIREELP--ENVPIGNIPKDLNISHINAATGTSASLVYR 65
            ::|:  |:.||: .|||  :.:.....:.|:.|  .::|:...||::.|     .:|..||  |.
 Worm     9 YFLI--LLGCLKGTDSAQLLIEPSFLLVEEDWPVGTHLPVTICPKNVKI-----LSGDPAS--YF 64

Human    66 LVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKI 130
            .|.|      :..:.||.::   :..:|.:|..|.....:.    |.| |:..|......::::|
 Worm    65 TVVK------INETCSTLQL---NLALDADKENADGLRGQS----FSL-VIAGPKKSRATLEVQI 115

Human   131 IVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVET 195
            :  |.|||:|.|.:...:..|.||..|.:.....:..|||||.:|:..:. :.|.|.|.|...:.
 Worm   116 V--DVNDNSPQFSNTPSSFEISENAEIGTDIFKVTTLDPDTGISGISRFS-VEGDSSFTLAKRKC 177

Human   196 PEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS----DVNDNRPVFKEGQ 256
            ..|:...||.:.:.||.|:|..:...|..:| |.|..:.|..:..||:    :.||..|.|....
 Worm   178 SSGKCSTQLRLAKKLDFEEKPIHTFNITAKD-GDPHSNRTHTVAHTVTIHVKNENDEPPKFLTDF 241

Human   257 VEVH-IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK--------RLFALNNTTGLI 312
            .:|. |.::...|..:.:|.|.|.:.|  |||:  ||.:.....|        .|..|.....||
 Worm   242 SQVFPIFKSTKPGDIIAKLEAIDVENG--AEIQ--FGMKENEHLKIDSKSGNVLLKKLPTDDALI 302

Human   313 TVQ----RSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLR-YIISPINGTVY 372
            ||:    .|.:.:...:.....|.:|.::.|       .:.:..:.|...:.. |....|.||..
 Worm   303 TVELYATSSKNGKSKTVEMKLRLMNDEATLP-------KIAENQEKPELCEFPIYEAHLIQGTGT 360

Human   373 LSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDN-----QYLLETSSLLDYEGT 432
            .|  .|:..|.......:|...:.|.....:.....||::....|     ..:|:::.||     
 Worm   361 FS--TPLKIKTLKSMAEEKPRLIGGSESFDLNVIDDFHVELKVLNAEKVASQVLDSAQLL----- 418

Human   433 KEFSFKIVASDSGK------------PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRG 485
                   |.|.||:            |..:..| .::|:      .|.|.:...:..|.| ||..
 Worm   419 -------VKSQSGQCRIVLRSAAQMTPKASPIA-QKLKI------IPKFEKSEYQFQVVE-NREP 468

Human   486 LYLTTISATDEDSGKNADIVYQ-LGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARD-NG 548
            ..|..:....:     ..:.|: ||.|...|.:. ..|.:......|||..|:|...|.|.| ||
 Worm   469 TVLGEVKVISD-----GPVTYEILGENGEKFQIS-NDGEIQNLEPIDRETYEKFELIVKATDLNG 527

Human   549 TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFV----SENLPKYSTVGVITVTDADAGENKAVTL 609
            :   ..::.:|:.|.|||||||.|...|:...|    ||.|.       ||.||||:|:|..:..
 Worm   528 S---SGKSQLIIHVKDENDNSPIFDKEHYFITVDEGKSEKLK-------ITATDADSGKNGQIVY 582

Human   610 SILNDNDNFVLD--P----YSGVIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKVTINV 665
            ||....||..:|  |    :.|.|      |||   ..:.....|.|:|.|:|.||::|.|||.|
 Worm   583 SIDQKIDNLPIDISPDGMLFIGAI------DRENMGNSNEVNLTVTASDSGEPKRSASATVTIRV 641

Human   666 MDVNDNSPVVISPPSNTSFKLVPLSA--IPGSVVAEVFAVDVD-TGMNAELKYT------IVSGN 721
            .|:||||||.    ||:.:. :||.|  .||.::..:.|.|.| |..|..:.||      .||.:
 Worm   642 KDINDNSPVF----SNSRYS-IPLDANISPGGIIGRLEATDADSTSPNNYVTYTSGDPKFTVSDS 701

Human   722 NKGLFRIDPVTG------------NITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
            .:.||     ||            |:|.::...|.: ..:.||| |::....||:...:...:..
 Worm   702 GEILF-----TGPGTLEKSASLEFNVTAQDGGDPMN-SANALVV-INEHRSMKSIENELTTQINS 759

Human   775 NDTAGNAS-----------YIYDLIRRTMETPLDRNIG------------------DSSQPYQNE 810
            |||.|..|           |.|::||.:.:...|..:.                  |.|:..|  
 Worm   760 NDTGGEKSEIKWLNAGMPGYTYEIIRASADGFSDSEVATWISIDSKSGRIYTLKKVDPSRVKQ-- 822

Human   811 DYLTIMIAIIAGAMVVIVVIFVTVL-------VRCRHASRFKAAQRSKQGAEWMSPNQE--NKQN 866
              :.:.|::..|...|.|.:.:.|:       :......:....:.:..|...:....|  .:||
 Worm   823 --IKLHISMRKGKREVPVELIINVMDTDDVTPIYSTPTRKLSVTESATLGTTVVDMPVEGIKEQN 885

Human   867 K-KKKRKKRKSPKSSLL--NFVTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDW-----GPA 923
            : |...|....|:..|.  .:.||:..|             ||..|.|:...|..:.     |.|
 Worm   886 EIKYSLKITSGPRGKLQIDRYGTIKIIK-------------SLDFETEQIIKGIVEGMVVKNGKA 937

Human   924 PPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSST-- 986
            ..::|      :.....:...:|.|....:..||:.:..|:..: ||..:....|..|.:.||  
 Worm   938 AKSSF------ILTILDANDNRPIFKNSSNFAVSLLESSVLGTV-LDLPYPLATDRDSSKFSTLK 995

Human   987 -----SSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEESHYE 1046
                 ...:|...|.:|.  .:...||.......||.|       .||..:.|      .|.|:|
 Worm   996 YSMTGDEGYFKIDESNST--IRLVAPLDFETQRVHSLS-------IKCVDNQG------REPHHE 1045

Human  1047 SQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISH-------------PLPLVQPQDEFYDQAS 1098
            ....||..:.|          :.|:.||...|.::|             .:.::...||     .
 Worm  1046 VFASVTVTVID----------VNDNAPVIHNTDLTHLSIEEDAQVGQVVTVLVISDSDE-----G 1095

Human  1099 PDKRTEADGNS 1109
            ..::||.|.||
 Worm  1096 GVQKTEIDVNS 1106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PCDH9NP_982354.1 Cadherin_repeat 29..138 CDD:206637 24/110 (22%)
Cadherin_repeat 146..248 CDD:206637 29/105 (28%)
Cadherin_repeat 258..354 CDD:206637 23/108 (21%)
Cadherin_repeat 370..465 CDD:206637 19/111 (17%)
Cadherin_repeat 473..568 CDD:206637 26/96 (27%)
Cadherin_repeat 576..671 CDD:206637 38/107 (36%)
Cadherin_repeat 687..776 CDD:206637 27/109 (25%)
Protocadherin 777..1000 CDD:462451 49/275 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 849..882 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 984..1035 12/57 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1055..1084 6/41 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1122 5/13 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1186..1237
cdh-8NP_001294412.1 Cadherin_repeat <55..121 CDD:206637 19/88 (22%)
Cadherin_repeat 131..232 CDD:206637 28/102 (27%)
Cadherin_repeat 457..544 CDD:206637 26/96 (27%)
Cadherin_repeat 552..647 CDD:206637 38/107 (36%)
Cadherin_repeat 656..741 CDD:206637 24/92 (26%)
Cadherin_repeat 861..952 CDD:206637 19/109 (17%)
Cadherin_repeat 964..1060 CDD:206637 26/121 (21%)
Cadherin_repeat 1184..1265 CDD:206637
Cadherin_repeat 1275..1375 CDD:206637
Cadherin_repeat 1396..1476 CDD:206637
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.