DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASCC1 and HUL5

DIOPT Version :9

Sequence 1:	NP_001185728.1	Gene:	ASCC1 / 51008	HGNCID:	24268	Length:	400	Species:	Homo sapiens
Sequence 2:	NP_011374.1	Gene:	HUL5 / 852736	SGDID:	S000003109	Length:	910	Species:	Saccharomyces cerevisiae

Alignment Length:	330	Identity:	74/330 - (22%)
Similarity:	108/330 - (32%)	Gaps:	151/330 - (45%)

- Green bases have known domain annotations that are detailed below.

Human   151 LLDTFRRKQPFTHFLAF-------------FLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQN 202
            ||.....:....|||:.             |||        |||.||:            ..:::
Yeast   409 LLSKVYERDSRLHFLSTENNPTYWENSEKQFLN--------LRFYEEL------------QEYED 453

Human   203 PKKLHLTIGMLVLLSEEEIQQTCE---------------MLQQCKEEFINDISGGKPLEV----- 247
            ..:.||         |||..:..|               :|.:.|:...:.:...| ||:
Yeast   454 LYREHL---------EEESDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSSLRFRK-LEILLELP 508

Human   248 ------EMAGIEYM-----------NDDPGMVDVL--YAKVHMKDGSNRLQELVDRVL------- 286
                  |...:.||           :||..::::.  :|...|:..|..:..  |.||
Yeast   509 FFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAIISR--DNVLEDAFNAF 571

Human   287 ----ERFQAS-----------------GLIVKEWNSVKLHATVMNTLFRKDPNAE-----GRYNL 325
                |||:||                 |.|.||:.:     ||.:..| |||..|     .||.|
Yeast   572 NSIGERFKASLDVTFINEFGEEAGIDGGGITKEFLT-----TVSDEGF-KDPKHELFRTNDRYEL 630

Human   326 Y------TAEGKYIFKERESFDGRNILK----------SFA---LLPRLEY-NDAISAHCNLCLP 370
            |      ..:.|||:     |.|:.:.|          |||   |...|.| |..:|:..:|
Yeast   631 YPSVVYDATKLKYIW-----FLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDL--- 687

Human   371 GSSDS 375
            ||.||
Yeast   688 GSYDS 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASCC1	NP_001185728.1	Required for interaction with ASCC3. /evidence=ECO:0000269\|PubMed:29997253	1..53
		vigilin_like_KH	99..148	CDD:239087
		PLN00108	157..370	CDD:177724	68/317 (21%)
		AKAP7_NLS	161..349	CDD:287446	59/288 (20%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	74/330 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900