DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ASCC1 and ascc1

DIOPT Version :9

Sequence 1:	NP_001185728.1	Gene:	ASCC1 / 51008	HGNCID:	24268	Length:	400	Species:	Homo sapiens
Sequence 2:	NP_001096371.1	Gene:	ascc1 / 100124965	XenbaseID:	XB-GENE-987795	Length:	355	Species:	Xenopus tropicalis

Alignment Length:	349	Identity:	206/349 - (59%)
Similarity:	266/349 - (76%)	Gaps:	30/349 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRA 65
            ||||||.||.|.||.||||.|:|.::|:||||||||:.|::|.|||||.:.||:|.:||:.|:..
Frog     1 MEVLRPTLINIGGRIYRKNAVREASHQNEEDEEDFYRESVQCLDEPCDDFTVEETEKGFQCTIDL 65

Human    66 PSLLYNLIHLNTSNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGE 130
            ||.|:                            ::|:||:|:|::.:|.||:|||.||:||.:|:
Frog    66 PSQLF----------------------------KYIIGKKGETKRNLESETRTSIIIPRPGVEGD 102

Human   131 IVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEVLAKCSMDHGV 195
            |:||||.|||||||||||::|.::|||||||||||:|.||..|:||..|.|:||||||||.|.||
Frog   103 IIITGQQRNGVISARTRIELLAESFRRKQPFTHFLSFALNHPEIQEKVLLFKEEVLAKCSKDRGV 167

Human   196 DSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPG 260
            :|||||||.|||||||.:|||||:|:.|..|:||:|||||::.|:|||.|::::.|||||||||.
Frog   168 ESSIFQNPAKLHLTIGTMVLLSEKEVMQANEILQKCKEEFLDKITGGKSLQLQVVGIEYMNDDPA 232

Human   261 MVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNL 325
            |||||||||.|||||.|||.:.||:::||.:|||::|||:.|||||||||||||:||.||.|.::
Frog   233 MVDVLYAKVEMKDGSERLQLIADRLMQRFVSSGLMLKEWDRVKLHATVMNTLFRRDPLAEERSSI 297

Human   326 YTAEGKYIFKERESFDGRNILKSF 349
              :.||...:||||||.||:||.|
Frog   298 --SAGKPGQRERESFDARNVLKIF 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASCC1	NP_001185728.1	Required for interaction with ASCC3. /evidence=ECO:0000269\|PubMed:29997253	1..53		33/51 (65%)
		vigilin_like_KH	99..148	CDD:239087	30/48 (63%)
		PLN00108	157..370	CDD:177724	129/193 (67%)
		AKAP7_NLS	161..349	CDD:287446	124/187 (66%)
ascc1	NP_001096371.1	vigilin_like_KH	62..121	CDD:239087	35/86 (41%)
ascc1	NP_001096371.1	AKAP7_NLS	133..354	CDD:371071	125/189 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I11762
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41079
Inparanoid	1	1.050	411	1.000	Inparanoid score	I8939
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206094at32523
OrthoFinder	1	1.000	-	-		FOG0005022
OrthoInspector	1	1.000	-	-		oto151245
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060