Protein Alignment ACOX1 and POX1

DIOPT Version :10

• Sequence 1: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_011310.1
• Gene: POX1 / 852667
• SGDID: S000003173
• Length: 748
• Species: Saccharomyces cerevisiae
• Alignment Length: 725
• Identity: 218/725 - (30%)
• Similarity: 357/725 - (49%)
• Gaps: 109/725 - (15%)

Human     1 MNPD---------LRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDP----DFQHEDLN 52
            :|||         :::||..:....:.:...|:.|||:......:.:.|:|||    |..:.|..
Yeast     7 INPDSVVLNPQKFIQKERADSKIKVDQVNTFLESSPERRTLTHALIDQIVNDPILKTDTDYYDAK 71

Human    53 FLTRSQRYEVAVRKSAIM----------VKK-------MREFGIADPDEIMWFKN---FVHRGR- 96
               :.|..|:..:|.|.:          |:|       |:|....|||:.....|   |:...|
Yeast    72 ---KMQEREITAKKIARLASYMEHDIKTVRKHFRDTDLMKELQANDPDKASPLTNKDLFIFDKRL 133

Human    97 -------PE---PLDLHLGMFLPTLLHQATAEQ-----QER--FFMPAWNLEIIGTYAQTEMGHG 144
                   |:   .:.:|||:|...:....|.||     |||  ..|..    |.|.:|.||:|||
Yeast   134 SLVANIDPQLGTRVGVHLGLFGNCIKGNGTDEQIRYWLQERGATLMKG----IYGCFAMTELGHG 194

Human   145 THLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPI 209
            :::..|:|.|.||.:...|::::|.:|:.|||.||...::.||.|.|:||.:||.||:..|:||:
Yeast   195 SNVAQLQTRAVYDKQNDTFVIDTPDLTATKWWIGGAAHSATHAAVYARLIVEGKDYGVKTFVVPL 259

Human   210 REIGTHKPLPGITVGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQV--KPDGTY---VKPL 269
            |:..|.:.|.|:::||||.|.|.|.||||:::..|..||||.||.::.:|  .|||:.   .:|.
Yeast   260 RDPSTFQLLAGVSIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVVRSPDGSVTVKTEPQ 324

Human   270 SNKLT-YGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFP 333
            .:::: |..::..|..:|.::.|..||..|||:||:..|.|...:.|..|.|::|:...||::.|
Yeast   325 LDQISGYSALLSGRVNMVMDSFRFGSKFATIAVRYAVGRQQFAPRKGLSETQLIDYPLHQYRVLP 389

Human   334 LLATAY-----AFQFVGAY---MKETYHRINEGIGQGDLS---ELPELHALTAGLKAFTSWTANT 387
            .|...|     ||:.:..|   :.|.|:..:.......::   :|..|...:|.|||..:|...|
Yeast   390 QLCVPYLVSPVAFKLMDNYYSTLDELYNASSSAYKAALVTVSKKLKNLFIDSASLKATNTWLIAT 454

Human   388 GIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSY-DQVHSGK----L 447
            .|:..|..|||||||..:|....|.::...||:||:|.|:.|.:|:.::|.: |....|:    |
Yeast   455 LIDELRQTCGGHGYSQYNGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILKKFIDSATKGRFDNTL 519

Human   448 VCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAARLVEIAAKNLQKEVIH---- 508
            .....|||        :||.:.   ::|.......|.|     .....||.:..|.|.:.|
Yeast   520 DVDSFSYL--------KPQYIG---SVVSGEIKSGLKE-----LGDYTEIWSITLIKLLAHIGTL 568

Human   509 -RKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKL----LKIQDKAIQAVLRSLCLLYSLYGIS 568
             .||:.:  :..|..||..|:.|....::|.:.:||    ..|.|:..:..:.::..|:|||.|.
Yeast   569 VEKSRSI--DSVSKLLVLVSKFHALRCMLKTYYDKLNSRDSHISDEITKESMWNVYKLFSLYFID 631

Human   569 QNAGDFLQGSIMTEPQITQVNQ-RVKELLTLIRSDAVALVDAFDFQDVTLGSVLGRYDGNVYENL 632
            :::|:|.|..|.|..||::|.| ::..||.::|.|.:.|.|:|:..|..|.|.:|.:||::|.|.
Yeast   632 KHSGEFQQFKIFTPDQISKVVQPQLLALLPIVRKDCIGLTDSFELPDAMLNSPIGYFDGDIYHNY 696

Human   633 F-EWAKNSPL 641
            | |..:|:|:
Yeast   697 FNEVCRNNPV 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	215/717 (30%)
POX1	NP_011310.1	AXO	18..702	CDD:173839	213/708 (30%)