Protein Alignment ACOX1 and Acox57D-d

DIOPT Version :10

• Sequence 1: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_523803.1
• Gene: Acox57D-d / 37446
• FlyBaseID: FBgn0034629
• Length: 677
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 255/678 - (37%)
• Similarity: 391/678 - (57%)
• Gaps: 30/678 - (4%)

Human     1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPD----FQHEDLNFLTRSQRYE 61
            :||||::||.:|.|:.|..:....|..:|.:::||||..|.:|.:    ..||   :::..:.|.
  Fly    12 VNPDLQKERAAAEFHVEEFSAWWHGGQDKLKKKREIEKAIFSDLEDGYGLNHE---YMSHEEVYN 73

Human    62 VAVRKSAIMVKKMREF------GIAD--PDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAE 118
            ..|:|.|....|::..      |..|  |..:...::|.......|:..|:.||:..:..|.|||
  Fly    74 STVKKVAEAAVKLKALQNKLNPGGTDIWPGGLFNAQSFGLFPANHPIATHITMFVDVIKGQGTAE 138

Human   119 QQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKT 183
            |.|::...|.|..|||||||||:.|||::|||.|.|.:||:|.||:||:|.:.:.||||||||.|
  Fly   139 QVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKTDEFVLNTPNLEAYKWWPGGLGHT 203

Human   184 SNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYLKMDNHRIP 248
            :|||:|:|||......:|:..||||:|:..||.||||:.:|:||.|.|...::.|:|.:::.|||
  Fly   204 ANHAMVVAQLYIADVHHGVQMFIVPLRDSETHMPLPGVDIGEIGKKLGMASVNQGFLGLNHVRIP 268

Human   249 RENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEIK 313
            |.|||||:|:|:.|||:....::::.|.|||:.|..:|.:.:..|..|.|||.||||||.||.|:
  Fly   269 RTNMLMKFAKVERDGTFKASPASRINYLTMVYTRCLIVSQNSTLLLAAATIATRYSAVRRQSPIE 333

Human   314 PGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLK 378
            |.:|||||:|..||:.||||.:||..|:.....||.|.|.:..:....|....||::|.|:..||
  Fly   334 PNQPEPQIIDHVTQRLKLFPEIATGIAYHLATEYMWEMYAQTVQEANNGKFERLPDMHILSCALK 398

Human   379 AFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVH 443
            ...:.....|||..|::.|||||...:.|.|||.|...:.|:||||||::||..|.|:|::....
  Fly   399 VLCTTDGCAGIEKLRLSTGGHGYLIAANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKAWASFV 463

Human   444 SGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAARLVEIAAKNLQKEVIH 508
            ..|.:....||.    :..:|.::...|.     :|.:.:.:|.:..||....||.:||...:..
  Fly   464 DKKPLSASYSYF----ASSMQLKEFPKWD-----DSWQCIIKALQYTAAHKTRIAFENLANRMAS 519

Human   509 RKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKL--LKIQDK--AIQAVLRSLCLLYSLYGISQ 569
            .:|:.||.|.|.::|.||:|.|....|.:.|.|::  .|.|.:  |:..:|.::..|:.:..:..
  Fly   520 GQSQGVAANNTGIELTRAAELHGRQFVCQTFLEQITGAKAQKRSPALNKILENVLELFLVQTVLN 584

Human   570 NAGDFLQGSIMTEPQITQVNQRVKELLTLIRSDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFE 634
            |..|.|:...:::..:..:.:|:::.|...|.:|||:.|.|:|.|..|.||||.||||||..||:
  Fly   585 NLNDILRFIKLSDADLRSLQKRLEDSLAQFRPNAVAICDGFEFHDRVLNSVLGSYDGNVYPRLFD 649

Human   635 WAKNSPLNKAEVHESYK-HLKSL-QSKL 660
            .||.|.:|:..|..|:: :||.| ::||
  Fly   650 SAKRSTMNQKPVQTSFETYLKPLMKAKL 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	243/649 (37%)
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:447864	244/650 (38%)