Protein Alignment ACOX1 and Acox57D-p

DIOPT Version :10

• Sequence 1: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_523802.1
• Gene: Acox57D-p / 37445
• FlyBaseID: FBgn0034628
• Length: 677
• Species: Drosophila melanogaster
• Alignment Length: 670
• Identity: 264/670 - (39%)
• Similarity: 372/670 - (55%)
• Gaps: 36/670 - (5%)

Human     1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHE-DLNFLTRSQRYEVAV 64
            :||||::|||:||||.|.......|..|..:..|.:...:..|.|.... .|...|..:..|.:.
  Fly    12 VNPDLQKERDAASFNSEEFAAWWAGGEEVLKFNRGVREYMEKDVDLSEMLQLQNKTHEEIIEFST 76

Human    65 RKSAIMVKKMREF-------------GIADPDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQAT 116
            |.:....||:|..             .:.|. ::||  ..|..|  .|..:...|.:..|..|.|
  Fly    77 RGAIEGAKKLRRLQEERNPGGDVYWPNLYDA-QVMW--GLVPGG--NPFGVMYVMLVKALQAQCT 136

Human   117 AEQQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLG 181
            .||.|.|.......||.|||||||:||||:||||||.|.:|.:|.:|:||:|.::|.||||||||
  Fly   137 PEQYEEFGKRVELFEICGTYAQTELGHGTYLRGLETRADFDRKTDQFVLNTPNISSYKWWPGGLG 201

Human   182 KTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYLKMDNHR 246
            .:|||.:|:|||...|.|.|.|.|.:.:|:..||:||||:.:||||.|.|:..::||:|.:.|.|
  Fly   202 HSSNHCLVMAQLYIDGDCKGPHMFFIQVRDEDTHEPLPGVHIGDIGKKMGFIGVNNGFLGLKNVR 266

Human   247 IPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSE 311
            |||..|||::||||.||:||...:|.|||..||..|..:....|..|:.|.|||.||||||.||.
  Fly   267 IPRTRMLMRHAQVKADGSYVSSPTNVLTYFAMVRTRCVIAKNNAVMLASAATIATRYSAVRRQSP 331

Human   312 IKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAG 376
            |.|.|.||||:|..|||.||||.:||:.|::..|.|:...|....|.|..|....|||||:|:..
  Fly   332 INPNEREPQIMDHVTQQMKLFPEIATSVAYRKAGDYLWNLYDVTIEDIENGKYERLPELHSLSCA 396

Human   377 LKAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQ 441
            ||...|..:.:|:|..|:||||||:...|.:.:|||:.|.:||:||||||::||..|||||::..
  Fly   397 LKVTCSMDSASGVEKLRLACGGHGFLTSSNMSSIYVSATAACTYEGENTVLLLQIGRFLMKTWRA 461

Human   442 VHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAARLVEIAAKNLQKEV 506
            ..:|..:...|.||.::...    .:...|     ..|.|::.:|.:..||...::|.::|.|.:
  Fly   462 ALTGAPLPPTVRYLAEVQKN----PEFGTW-----TGSWENMVKAMQYAAANRTQLAFRSLSKRM 517

Human   507 IHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQA----VLRSLCLLYSLYGI 567
            ...:::..|.|.|.::..:|:|.|....|...|.|.:...|.|...|    ||.:|..||.:...
  Fly   518 SRGETEANAANHTGIEFTQAAELHGRAFVFSAFYEAVTGPQSKTRSANFNRVLENLLELYLVKET 582

Human   568 SQNAGDFLQGSIMTEPQITQVNQRVKELLTLIRSDAVALVDAFDFQDVTLGSVLGRYDGNVYENL 632
            ....|..|:...:|:..::.:..|::.:||.:|.||||:||.|||.|:.|.|.||.||||.||.:
  Fly   583 LNQMGHLLRFINLTDTDLSGLQDRLETVLTKLRPDAVAIVDGFDFSDLQLNSTLGSYDGNAYERI 647

Human   633 FEWAKNSPLNKAEV----HE 648
            |:.|..:|:|:..|    ||
  Fly   648 FDAALKNPMNQKAVPKYFHE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	257/651 (39%)
Acox57D-p	NP_523802.1	ACAD	14..653	CDD:447864	258/652 (40%)