Protein Alignment ACOX1 and Acox57D-p

DIOPT Version :9

• Sequence 1: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_001286677.1
• Gene: Acox57D-p / 37445
• FlyBaseID: FBgn0034628
• Length: 677
• Species: Drosophila melanogaster
• Alignment Length: 669
• Identity: 264/669 - (39%)
• Similarity: 373/669 - (55%)
• Gaps: 34/669 - (5%)

Human     1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHE-DLNFLTRSQRYEVAV 64
            :||||::|||:||||.|.......|..|..:..|.:...:..|.|.... .|...|..:..|.:.
  Fly    12 VNPDLQKERDAASFNSEEFAAWWAGGEEVLKFNRGVREYMEKDVDLSEMLQLQNKTHEEIIEFST 76

Human    65 RKSAIMVKKMREF--------GIADPD----EIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATA 117
            |.:....||:|..        .:..|:    ::||  ..|..|  .|..:...|.:..|..|.|.
  Fly    77 RGAIEGAKKLRRLQEERNPGGDVYWPNLYDAQVMW--GLVPGG--NPFGVMYVMLVKALQAQCTP 137

Human   118 EQQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGK 182
            ||.|.|.......||.|||||||:||||:||||||.|.:|.:|.:|:||:|.::|.||||||||.
  Fly   138 EQYEEFGKRVELFEICGTYAQTELGHGTYLRGLETRADFDRKTDQFVLNTPNISSYKWWPGGLGH 202

Human   183 TSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYLKMDNHRI 247
            :|||.:|:|||...|.|.|.|.|.:.:|:..||:||||:.:||||.|.|:..::||:|.:.|.||
  Fly   203 SSNHCLVMAQLYIDGDCKGPHMFFIQVRDEDTHEPLPGVHIGDIGKKMGFIGVNNGFLGLKNVRI 267

Human   248 PRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI 312
            ||..|||::||||.||:||...:|.|||..||..|..:....|..|:.|.|||.||||||.||.|
  Fly   268 PRTRMLMRHAQVKADGSYVSSPTNVLTYFAMVRTRCVIAKNNAVMLASAATIATRYSAVRRQSPI 332

Human   313 KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGL 377
            .|.|.||||:|..|||.||||.:||:.|::..|.|:...|....|.|..|....|||||:|:..|
  Fly   333 NPNEREPQIMDHVTQQMKLFPEIATSVAYRKAGDYLWNLYDVTIEDIENGKYERLPELHSLSCAL 397

Human   378 KAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQV 442
            |...|..:.:|:|..|:||||||:...|.:.:|||:.|.:||:||||||::||..|||||::...
  Fly   398 KVTCSMDSASGVEKLRLACGGHGFLTSSNMSSIYVSATAACTYEGENTVLLLQIGRFLMKTWRAA 462

Human   443 HSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAARLVEIAAKNLQKEVI 507
            .:|..:...|.||.::...    .:...|     ..|.|::.:|.:..||...::|.::|.|.:.
  Fly   463 LTGAPLPPTVRYLAEVQKN----PEFGTW-----TGSWENMVKAMQYAAANRTQLAFRSLSKRMS 518

Human   508 HRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQA----VLRSLCLLYSLYGIS 568
            ..:::..|.|.|.::..:|:|.|....|...|.|.:...|.|...|    ||.:|..||.:....
  Fly   519 RGETEANAANHTGIEFTQAAELHGRAFVFSAFYEAVTGPQSKTRSANFNRVLENLLELYLVKETL 583

Human   569 QNAGDFLQGSIMTEPQITQVNQRVKELLTLIRSDAVALVDAFDFQDVTLGSVLGRYDGNVYENLF 633
            ...|..|:...:|:..::.:..|::.:||.:|.||||:||.|||.|:.|.|.||.||||.||.:|
  Fly   584 NQMGHLLRFINLTDTDLSGLQDRLETVLTKLRPDAVAIVDGFDFSDLQLNSTLGSYDGNAYERIF 648

Human   634 EWAKNSPLNKAEV----HE 648
            :.|..:|:|:..|    ||
  Fly   649 DAALKNPMNQKAVPKYFHE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	257/650 (40%)
		PLN02443	5..651	CDD:178062	261/665 (39%)
Acox57D-p	NP_001286677.1	ACAD	14..653	CDD:299127	258/651 (40%)
		PLN02443	16..677	CDD:178062	261/665 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2457
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1212
Isobase	1	0.950	-	0	Normalized mean entropy	S1686
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	1	1.000	-	-		mtm8477
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790