Protein Alignment ACOX1 and CG5009

DIOPT Version :9

• Sequence 1: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_611264.2
• Gene: CG5009 / 37028
• FlyBaseID: FBgn0027572
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 671
• Identity: 294/671 - (43%)
• Similarity: 421/671 - (62%)
• Gaps: 31/671 - (4%)

Human     1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHE-DLNFLTRSQRYEVAV 64
            :||||::||.:|:|||...:.:..|..|:.:.::.:|.:.|.||..|.: .:::|:..:.||.::
  Fly     6 VNPDLQKERSTATFNPREFSVLWAGGEERFKEKKALEKLFLEDPALQDDLPISYLSHKELYEHSL 70

Human    65 RKSAIMVKKMREFGIADPDEIMWFKNFVHRG--------RPEPLDLHLGMFLPTLLHQATAEQQE 121
            ||:.|:.:|:|:.. ||.::.:...|.:..|        ...||.||..||:||::.|.|.:||.
  Fly    71 RKACIIGEKIRKLR-ADGEDGVDTYNALLGGSLGSAILKEGNPLALHYVMFVPTIMGQGTMDQQV 134

Human   122 RFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNH 186
            .:...||:.||||||||||:||||.||||||.|.||..||||::|:|::::.||||||||.|:||
  Fly   135 EWLSKAWDCEIIGTYAQTELGHGTFLRGLETRADYDASTQEFVINTPSLSAYKWWPGGLGHTANH 199

Human   187 AIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYLKMDNHRIPREN 251
            |:|:|||.|||:..||..|||.:|:..||:|:|||.:||||.|.|...::||||.:.|.|:|..|
  Fly   200 AVVVAQLYTKGEFRGLAPFIVQLRDSDTHRPMPGIDIGDIGTKLGMKGVNNGYLGLKNVRVPLNN 264

Human   252 MLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEIKPGE 316
            ||||..||.||||||.|.::.||||||:|||..|:.:.|::|:||.|||.||||||.||.|.|.:
  Fly   265 MLMKNQQVLPDGTYVAPKNSVLTYGTMMFVRCALIRDTAQSLAKASTIATRYSAVRRQSPIDPNQ 329

Human   317 PEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFT 381
            |||||:|..|||.||||.:|.|..|:..|..:...|:.|:..|.||:|..|||:|||:..|||..
  Fly   330 PEPQIMDHTTQQLKLFPQIAKAIVFKTTGDGIWNMYNVISGEIEQGNLDRLPEMHALSCCLKAIC 394

Human   382 SWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGK 446
            |..|..|:|.||::||||||..||..|.||...|..||:|||||||:|||||:|:|.|.|..:|:
  Fly   395 SADAAAGVETCRLSCGGHGYMDCSNFPTIYGMTTAVCTYEGENTVMLLQTARYLVKVYGQALNGE 459

Human   447 LVCGMVSYLNDLPSQRIQPQQVAVWPTMVDIN-SPESLTEAYKLRAARLVEIAAKNLQKEVIHRK 510
            .:...|||::|..:|          ...|:.: |..|:.:|::..||....||.:.::   :.||
  Fly   460 KLVPTVSYISDAINQ----------TKFVNFDGSLRSIVKAFQFVAANKTRIAYEQIE---LRRK 511

Human   511 ---SKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKA---IQAVLRSLCLLYSLYGISQ 569
               ..|||.||....|..|::.|....:.:....:||.:..:.   :..||:.:..||.:.....
  Fly   512 QGYGTEVAANLCGTFLTAAADLHGRAFLAQTAYTELLALSREVSPELAEVLKVVLELYLVDACLN 576

Human   570 NAGDFLQGSIMTEPQITQVNQRVKELLTLIRSDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFE 634
            ..||||:...:|:..:|::..|::..|...|.:||:|||:||..|..|.|.||.|||||||::||
  Fly   577 RIGDFLRFIDLTDQDVTKLEVRLENCLKRFRPNAVSLVDSFDLHDRVLDSALGAYDGNVYEHIFE 641

Human   635 WAKNSPLNKAEVHESY-KHLK 654
            ..|.:||||..|:.:: |:||
  Fly   642 STKKNPLNKEPVNGAFHKYLK 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	284/649 (44%)
		PLN02443	5..651	CDD:178062	288/662 (44%)
CG5009	NP_611264.2	AXO	8..645	CDD:173839	284/650 (44%)
		PLN02443	10..669	CDD:178062	291/667 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2457
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38299
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1212
Isobase	1	0.950	-	0	Normalized mean entropy	S1686
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	1	1.000	-	-		mtm8477
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	LDO	PTHR10909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2020
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820