DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX22 and tbx22

DIOPT Version :9

Sequence 1:	NP_001103348.1	Gene:	TBX22 / 50945	HGNCID:	11600	Length:	520	Species:	Homo sapiens
Sequence 2:	XP_005157203.1	Gene:	tbx22 / 556143	ZFINID:	ZDB-GENE-090626-2	Length:	444	Species:	Danio rerio

Alignment Length:	499	Identity:	215/499 - (43%)
Similarity:	283/499 - (56%)	Gaps:	97/499 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     5 SRARAFSVEALVGRPSKRKLQDPIQAEQPELREKKGGEEEEERRSSAAGKSEPLEKQPKTEPSTS 69
            :|.:...||    ......|||.::.:...||...  .:.::.|.||.      |::|
Zfish    14 NRCKKMKVE----NRENESLQDVLEYDSDTLRRTL--FDAQDLRKSAK------ERKP------- 59

Human    70 ASSGCGSDSGYGNSSESLEEKDIQMELQGSELWKRFHDIGTEMIITKAGRRMFPSVRVKVKGLDP 134
                .|:::          .:.::::||||:|||||::|||||||||.|||||||:||||..|||
Zfish    60 ----AGAEA----------VRKVRVDLQGSDLWKRFYEIGTEMIITKVGRRMFPSIRVKVHNLDP 110

Human   135 GKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRM 199
            .:||.:|:|::|:|||:||||||||||::||||||.||.|..|||||||||||.||||:|||||:
Zfish   111 LQQYSIAMDIMPMDSKKYRYVYHSSQWVIAGNTDHSCIPPHLYVHPDSPCSGENWMRQVISFDRV 175

Human   200 KLTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLS-QIQSLPTEGVKTFSFKETEFTTVTAYQ 263
            ||||||:||:|||||:|||||:||:|||.......|| ::.|||.:||.||||.||:||||||||
Zfish   176 KLTNNELDDRGHIILKSMHKYRPRIHVILHCPPECLSKRLLSLPADGVFTFSFPETQFTTVTAYQ 240

Human   264 NQQITKLKIERNPFAKGFRDTGRNRGVLDGLLETYPWRPSFTLDFKTFGADTQ-----SGSSGSS 323
            |||||||||:|||||||||:  ||..||||:||:|.|...|. .||:...:.|     |.:||.:
Zfish   241 NQQITKLKIDRNPFAKGFRE--RNGAVLDGILESYSWHSPFN-GFKSLAMELQGRCFGSSASGIT 302

Human   324 PVTSSGGAPSPLNSLLSPLCFSPMFHLPTSSLGMPCPEAYLPNVNLPLCYKICPTNFWQQQPLVL 388
            |..||..|..| .:..||.|..   .||:|     |..||     ...| .||..|:...:|
Zfish   303 PSVSSAQAVHP-TAFSSPQCCK---ILPSS-----CFLAY-----RAYC-SICLNNYTGLRP--- 349

Human   389 PAPERLASSNSSQSLAPLMMEVPMLSSLGVTNSKSGSSEDSSDQYLQAPNSTNQM---LYGLQSP 450
                              |:::|:|:||.|   |.|....|...|..|..|.:.:   |.|..|
Zfish   350 ------------------MLDLPLLTSLPV---KKGDRCRSHWLYNSAGTSMHPIHNTLSGWAS- 392

Human   451 GNIFLPNSITPEALSCSFHPSYDFYRYNFSMPSRLISGSNHLKV 494
                 .|..|..|....       :.|:|.:..|..:.::|||:
Zfish   393 -----ENENTASAFMSP-------HSYSFPISHRFSTDTHHLKL 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX22	NP_001103348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		14/85 (16%)
TBX22	NP_001103348.1	TBOX	91..287	CDD:238106	141/196 (72%)
tbx22	XP_005157203.1	TBOX	67..260	CDD:238106	140/192 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I7303
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D293180at7742
OrthoFinder	1	1.000	-	-		FOG0011245
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120508
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	9	9.320