Protein Alignment SHANK1 and shank1

DIOPT Version :10

• Sequence 1: XP_011525315.1
• Gene: SHANK1 / 50944
• HGNCID: 15474
• Length: 2169
• Species: Homo sapiens
• Sequence 2: XP_068074207.1
• Gene: shank1 / 568908
• ZFINID: ZDB-GENE-130530-691
• Length: 2509
• Species: Danio rerio
• Alignment Length: 2721
• Identity: 1151/2721 - (42%)
• Similarity: 1362/2721 - (50%)
• Gaps: 821/2721 - (30%)

Human     5 PATSEDEERHSASE---CPEGGSES------------DSSPD---GPG--RGPR--GTRGQGS-- 45
            |...|:||.....:   ..|.|.|.            |...|   |||  ||.|  |.|.:|:
Zfish    26 PGAEEEEEEEEEMDDDGMDEEGEEENGELEMDDEEEVDDEDDIRRGPGHLRGGREEGHRQKGTMA 90

Human    46 -----------GAPGSLAS---------------------VRGLQGRSMS-VPDDAHFSMMVFRI 77
                       |.||..|:                     .|.|:.||.| .|||.|.::|||||
Zfish    91 GRLPGDRPIRPGNPGHAANPYSSNPGPTHQTSTNQQQQQPQRKLRERSSSNAPDDTHVALMVFRI 155

Human    78 GIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYP 142
            ||||:.||||||||||||:|.|||||:|:|:|||:||||||||||||.|.||.||||||.|||||
Zfish   156 GIPDIKQTKCLRFNPDATVWKAKQQVMCSLTESLRDVLNYGLFQPATDGHDAKFLEEERPLREYP 220

Human   143 QSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNY 207
            |||||||||||||||||||||||||||||||||||..||||::|:|....:|||:|:||||||||
Zfish   221 QSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKASLKKFMDYIQTSAVEKVAKLIDKGLDPNY 285

Human   208 HDSDSGETPLTLAAQTE-GSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGG 271
            ||.|:||||||||.||| |..|:||.|.:||||||||||||:|.||||..|....||..||.||.
Zfish   286 HDPDTGETPLTLAVQTEPGGSEIIRVLVMGGAHIDFRARDGLTPLHKAVRAHAHTALLTLLSLGA 350

Human   272 SPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFY 336
            |.:|||.||||||:||.::|||..|||.||::||:||:.|||||.|.|||||.|:||||||||||
Zfish   351 SSDYKDSRGLTPLYHTVLIGGDTSCCETLLYHRARLGLRDENGWDETHQACQNGNSQHLEHLLFY 415

Human   337 GAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRN 401
            ||:..:||||||||||||||||||:||||||||||.||.|||:||..|||||::|:|||||:|:|
Zfish   416 GADSSSQNASGNTALHICALYNKESCARILLYRGAKKDTKNNSGQNSFQVAVMSGHFELGEIIKN 480

Human   402 HREQDVVPFQESPKYAARRRGPPGT-GLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPT 465
            |||.|||||.||||||.:||....| ||..|...||||||.||.:|||:.|  |.||.|......
Zfish   481 HRESDVVPFLESPKYAPQRRESSRTLGLPHPHPFLRANSDNSMNVPDWIAF--PNAAGSSIVSVQ 543

Human   466 SGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGR--HPEDAKRQPRGRPSSSGTPREGPA 528
            ....|             |||||:|||||||.|||||||  ..:|..||.|||..:.....:|.|
Zfish   544 GLKHG-------------GTLRSSSSPRGARTRSPSRGRTGDRDDRSRQTRGRQGAGSISSQGTA 595

Human   529 GGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWE 593
            .               |:||:||||||||.|:|.:|:.||.:.|||.:||:|:||||:||||:||
Zfish   596 S---------------GQRRRLYSAVPGRVFVATRSHSAQGDREISFNKGDKVKVLSVGEGGYWE 645

Human   594 GQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYI 658
            |.|:||.|||||||:||||.||.||:.||||::|||||||||||||||||||         ||||
Zfish   646 GTVRGRTGWFPSDCVEEVALRSLESRSESRSERAKRLFRHYTVGSYDSFDAP---------SDYI 701

Human   659 IKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLI 723
            ||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   702 IKEKTVLLQKKDNEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLI 766

Human   724 EVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKS 788
            ||||||||||||||||||||||||:||||||||||:|||:|.|.||.|||:|||..|.|:|||||
Zfish   767 EVNGQNVVKVGHRQVVNMIRQGGNSLMVKVVMVTRNPDMEEGVRKKIPQQSKRLSTPAIALRSKS 831

Human   789 MTSELEEM----------------------------------------------VSPWKKKSEYE 807
            ||||||||                                              .:|||||||:|
Zfish   832 MTSELEEMEVPHCHYQHPHYRTQGLFLVTCLTNLSCNLPNFSVCPGIPYTVDRASAPWKKKSEFE 896

Human   808 QQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDP 872
            ...|    .|||||||||||||||||||||||||:.:|:||| .:..:.:.|.:||: .|.:||.
Zfish   897 SSQA----TEKKRTVYQMALNKLDEILAAAQQTINTNEAPGP-RVQGVKRERGRGFY-NEPNFDQ 955

Human   873 HHRAQPS------YERPSFL----PPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSED 927
            ......|      |:|..|:    ||..  ||||||||..|:::.:|.||||||:|||||||.::
Zfish   956 TGMGMTSSGAGLGYDRGQFVSGHGPPHG--MLRQKSIGVPEEEKQFLHPPAMKFARSLSVPGPDE 1018

Human   928 IPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSRE 992
            |||||||:|||||:|:.|                             |..|.|.:       |::
Zfish  1019 IPPPPTTAPPEPPFSSAP-----------------------------PLGFRGKT-------SQQ 1047

Human   993 KSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALG---PQPS 1054
            .|:..|.....|.|:..:....|.    .|......|.||   ||....|    ||..   ..||
Zfish  1048 PSVSMSQSTSSAAHYQLYSQSVHV----THGPRDRSPGPP---TGSGTGD----LAYSHAQAHPS 1101

Human  1055 LRGWRGGGPSPTPGAPSPSHHGSAGGGGG--SSQGPALR--YFQ-LPPRAASAAMYVPA------ 1108
            :       ||.|.......:.|...|.||  .::..|||  |.. :||  .|.|..:|.
Zfish  1102 V-------PSRTASRKVIGYTGDLAGAGGVAGAKAAALRRGYSNAVPP--TSVATVIPQQQQTTQ 1157

Human  1109 -------RSGRG-------------RKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVA 1153
                   |||.|             .|||||||:|||...|....|....|
Zfish  1158 NQPSRMDRSGMGVGAGGVPKGGARRGKGPLVKQSKVEDLRQGQDTLEAKVS-------------- 1208

Human  1154 APSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPP-------TQPEPTGGGGGGGSSPSPAPA 1211
              .||:||||||||:||||||||||||||||.|||||       ::|||.        .|.|||.
Zfish  1209 --VEKSSIPIPTIIVKAPSTSSSGRSSQGSSVEAEPPPPGESDSSKPEPV--------VPPPAPT 1263

Human  1212 MSPVPPSPSPVPTPASPSGPA-----TLDFTSQFGAALVGAARREGGWQNEARRRS-TLFLSTDA 1270
            :.  ||:|..:|.|..||.|:     :||||||||||:||||||:....:||||:| :.|||  |
Zfish  1264 VP--PPAPPSIPAPPPPSLPSLRTQESLDFTSQFGAAIVGAARRDRERFHEARRKSASFFLS--A 1324

Human  1271 GDEDGGDGGLG---------TGAAPGPRLRHSKSIDEGMFSAEPYLR----------LESAGSGA 1316
            .:|..|.||.|         ..:.|.||||.||||||||||.:.::.          |....|.|
Zfish  1325 EEELSGAGGAGGRTQTSQQQLSSQPSPRLRPSKSIDEGMFSGDTFIHHTRSMPPAFGLPEYSSPA 1389

Human  1317 GYGG----------YGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERA 1371
            ..|.          ||||||.........|     |....:||||||.|||:|||||||||||||
Zfish  1390 PQGDYQPKSVPADFYGAGSRQQQQQQQQQA-----PTTTFIHPLTGKVLDPSSPLGLALAARERA 1449

Human  1372 LKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGS 1436
            ||:..               |......|.||.:                     |:|. ..|..|
Zfish  1450 LKDDG---------------RIRRERTTEHHFT---------------------RQLS-SIGAFS 1477

Human  1437 QEKSLPASP---PAARRSLLHRLPPTAPGVGPLLL--------QLGTEPPAPH--PGVSKPW--- 1485
            ...|.|.|.   |.|..|........:......|:        ...|.||:|.  .|....|
Zfish  1478 SSTSQPTSHISYPMASSSSATSSAAQSTNTSSYLVTSSSLAATTTSTRPPSPRILRGAGSSWSEE 1542

Human  1486 --------RSAAPEEPERLPLHVRFLEN------------------------------------- 1505
                    |.||.....|..|.|||.|:
Zfish  1543 AGVGERADREAAGTSAPREGLRVRFSEDKTVHTHHYQSQQYQPTFKERERERQRERSRERERERE 1607

Human  1506 ---------------------CQPRAPVTSGRGPPSEDGPGV----PPPSPRRSVPPSPTSPRAS 1545
                                 .|||.|  |.....||.|..:    ||..|..:.|..||:....
Zfish  1608 REREIEKAQTQYQQQSSQPMTQQPRRP--SFLRMESEAGAYILSLTPPSPPPTAAPMRPTAGATG 1670

Human  1546 EE-NGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEK----------------PESPLT 1593
            |. :|..|:||||||||||.:| ||:|.:||||||||:|||::                ...|..
Zfish  1671 ESGSGTSLMVLPPPAPSVDADD-EFVFADPLPPPLEFANSFDRGLGYSAMISHNVAARQQRHPPP 1734

Human  1594 PGPPHPLPD------TPAPA-TPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGA-SAAP 1650
            |.||.|.|.      |..|| ||||         :|...|||.|||||||||||.|||.| |.:|
Zfish  1735 PPPPPPPPTSKDSFMTGFPAHTPLP---------SPQAGDSTTSSLTSYDSEVANLTQSAPSPSP 1790

Human  1651 GDPH--------------PPGPPAPAAPAP--------------------------AAPQP---- 1671
            ..|:              ||.||:.:.|.|                          ::|.|
Zfish  1791 SSPNPLPPHSPSTLQTSGPPPPPSVSPPPPPNSYHRPFGLSQSQHLYNSTHTTGRSSSPTPPLSI 1855

Human  1672 -------GP-------------------------------------------------------- 1673
                   ||
Zfish  1856 PAPPAYRGPPTASSTPATSVSIRGASTVTASCSTTASTTVTSPSTTAAATPHTRIATVSTVATGG 1920

Human  1674 --------DPPPG-----------TDSGIEEVDSRSSSDHPLETI---SSASTLSSLSAEGGGSA 1716
                    .|||.           .||||||:||||||||.|::|   |.:.....|...|..|.
Zfish  1921 SRRPSAEHHPPPSATKSGESQETVVDSGIEELDSRSSSDHHLDSILALSGSGVRERLERAGMSSI 1985

Human  1717 GGGGGAGAGV----ASGPELLDTYVAYLDGQAF----GGSSTPGPPYPP---------------Q 1758
            ||.||.....    .||.:.|::|::|||||.|    ..:::....||.               |
Zfish  1986 GGIGGRDGATEVDRTSGADFLESYMSYLDGQTFEMHNAKAASTASTYPKTQRYREGTRAGDLRRQ 2050

Human  1759 LMT--PSKLRGRA---------------LGASG--GLRPGPSGGLRDPV----TPTSPTVS-VTG 1799
            ..|  |:..|.|.               |.|..  |:|.|| |..|..|    .|.:|.:. :.|
Zfish  2051 TSTAPPAYHRRREEEEEEDEAEEVEEEDLSARDGYGMREGP-GIARSSVMYFDRPRTPEIKPLWG 2114

Human  1800 AGTDGLLALRACSGPPTAGVAGGPVA---VEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPG 1861
            .|:.|        ...|.|..||.:.   ||              ||||          .||:.|
Zfish  2115 DGSTG--------ASQTMGEGGGQIVGTYVE--------------PRKL----------HPPMTG 2147

Human  1862 PLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSS 1926
                        :||:||:|||:||||     .:.|...|              ||.      .|
Zfish  2148 ------------MKANIINELSTKLQQ-----RSKGTENW--------------GAQ------RS 2175

Human  1927 LQRQRLSDDSQSSL--------------LSKPVSS---------LFQNWPKPPLPPLPTGTGVSP 1968
            |.|.|.|:||..:|              ||:|..|         |:.||.:.|.|..|..:...|
Zfish  2176 LSRHRFSEDSTGALSPPSVRSSSPSPVQLSQPALSPSPTPSSQPLYSNWARSPSPQPPAASSQPP 2240

Human  1969 TAAAAPGATSPSA-SSSSTSTRH-----LQGVEFEMRP-----------PLLRRAPSPSLLPASE 2016
            ..:.:|  .|||: |...||.:|     .:.:||:..|           ...||||||.:.|:..
Zfish  2241 PRSHSP--VSPSSYSPYPTSPKHRPVYRTKALEFQFIPSRESRKSESHHAQRRRAPSPLISPSDR 2303

Human  2017 HKVSPAPRPSSLPILPSGPLYPGLFDIRGS--PTGGAGGSADP--------FAPVFVPPHPGISG 2071
            .|:.| ||||||||||:.|||..|:|:|||  |...|....||        |||...||.|..|
Zfish  2304 PKLGP-PRPSSLPILPTTPLYSSLYDLRGSITPPSPANPLGDPYFSPSPPLFAPSGAPPPPNSS- 2366

Human  2072 GLGGALSGASRSLSPTRLLS--------------------LP---PDKPFGAKPLGFWTKFDVAD 2113
                  ...|||||||..||                    ||   |.|||.:|||.:|||:||||
Zfish  2367 ------LVVSRSLSPTHFLSGTSSPPLHPIPPPTCLSYPHLPPPSPTKPFASKPLPYWTKYDVAD 2425

Human  2114 WLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER 2169
            ||.:|.|.|||.:|||:||||:|||:|||:||:|||||||||||||:|||:..::|
Zfish  2426 WLGYLNLGEHRERFLDNEIDGTHLPSLTKDDYLDLGVTRVGHRMNIERALRRVMDR 2481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHANK1	XP_011525315.1	FERM_F0_SHANK1	70..158	CDD:340695	72/87 (83%)
		ANKYR	166..407	CDD:440430	172/241 (71%)
		ANK repeat	212..244	CDD:293786	23/32 (72%)
		ANK repeat	246..277	CDD:293786	16/30 (53%)
		ANK repeat	279..344	CDD:293786	44/64 (69%)
		ANK repeat	346..377	CDD:293786	27/30 (90%)
		SH3	557..608	CDD:473055	32/50 (64%)
		PDZ_SHANK1_3-like	656..757	CDD:467228	98/100 (98%)
		SAM_Shank1,2,3	2102..2167	CDD:188905	47/64 (73%)
shank1	XP_068074207.1	Ubl1_cv_Nsp3_N-like	148..236	CDD:475130	72/87 (83%)
		ANKYR	244..479	CDD:440430	167/234 (71%)
		ANK repeat	291..323	CDD:293786	23/31 (74%)
		ANK repeat	325..356	CDD:293786	16/30 (53%)
		ANK repeat	358..423	CDD:293786	44/64 (69%)
		ANK repeat	425..456	CDD:293786	27/30 (90%)
		SH3_Shank	610..659	CDD:212766	30/48 (63%)
		PDZ_SHANK1_3-like	699..800	CDD:467228	98/100 (98%)
		PHA03247	<2276..2416	CDD:223021	56/147 (38%)
		SAM_Shank1,2,3	2414..2479	CDD:188905	47/64 (73%)