Protein Alignment SHANK1 and Shank1

DIOPT Version :10

• Sequence 1: XP_011525315.1
• Gene: SHANK1 / 50944
• HGNCID: 15474
• Length: 2169
• Species: Homo sapiens
• Sequence 2: NP_001029287.1
• Gene: Shank1 / 243961
• MGIID: 3613677
• Length: 2167
• Species: Mus musculus
• Alignment Length: 2175
• Identity: 2037/2175 - (93%)
• Similarity: 2074/2175 - (95%)
• Gaps: 14/2175 - (0%)

Human     1 MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVP 65
            |||||||||||||||||||||||||||||||||||||:||||:||||||:|||.|||||||||||
Mouse     1 MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPQGTRGRGSGAPGNLASTRGLQGRSMSVP 65

Human    66 DDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDAN 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 DDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDAN 130

Human   131 FLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 FLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKV 195

Human   196 ARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHC 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 ARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHC 260

Human   261 LALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRG 325
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   261 LALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLYNRAQLGIADENGWQEIHQACQRG 325

Human   326 HSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIA 390
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   326 HSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGANKDVKNNNGQTPFQVAVIA 390

Human   391 GNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPG 455
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Mouse   391 GNFELGELIRNHREQDVVPFQESPKYAARRRGPPGAGLTVPPALLRANSDTSMALPDWMVFSAPG 455

Human   456 AASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSS 520
            |:|||.||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   456 ASSSGTPGPTSGSQGQSQPSAPSTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSS 520

Human   521 GTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLS 585
            ||||:|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Mouse   521 GTPRDGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQGEGEISLSKGEKIKVLS 585

Human   586 IGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDG 650
            ||||||||||||||||||||||||||||||||.:||||||||||||||||||||||||||||:||
Mouse   586 IGEGGFWEGQVKGRVGWFPSDCLEEVANRSQEGRQESRSDKAKRLFRHYTVGSYDSFDAPSLIDG 650

Human   651 IGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAG 715
            |..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 IDSGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAG 715

Human   716 LRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPP 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Mouse   716 LRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKASQQAKRLPPP 780

Human   781 TISLRSKSMTSELEEMVSPWKKKSEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASE 845
            .||||||||||||||||||||||.|||||||.|||||||||||||||||||||||||||||||||
Mouse   781 AISLRSKSMTSELEEMVSPWKKKIEYEQQPAAVPSMEKKRTVYQMALNKLDEILAAAQQTISASE 845

Human   846 SPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLA 910
            ||||||||||||||||||||||||||||||:||||:|||||||||||||||||||||||||||||
Mouse   846 SPGPGGLASLGKHRPKGFFATESSFDPHHRSQPSYDRPSFLPPGPGLMLRQKSIGAAEDDRPYLA 910

Human   911 PPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSP 975
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Mouse   911 PPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPAPSSSGRLTPSPRGGPFNPGSGGPLPASSP 975

Human   976 ASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSP 1040
            :|||||||||.|.|.|||||||||.||||||||||||||||||||||||||||||||||||||||
Mouse   976 SSFDGPSPPDPRSGGREKSLYHSGALPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSP 1040

Human  1041 DDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMY 1105
            ||||||||||||||||||||||||||.||||||||.|:||..|.:|.||||||||||||||||||
Mouse  1041 DDPPPRLALGPQPSLRGWRGGGPSPTSGAPSPSHHSSSGGSSGPAQAPALRYFQLPPRAASAAMY 1105

Human  1106 VPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKA 1170
            ||||||||||||||||||||||||| |.||||.||||||.|:..|..|.||||||||||||||||
Mouse  1106 VPARSGRGRKGPLVKQTKVEGEPQK-GSLPPASSPTSPALPRSEPPPAGPSEKNSIPIPTIIIKA 1169

Human  1171 PSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLD 1235
            |||||||||||||||||||||||:   |.||||||||||||.|||||||||||||||||||||||
Mouse  1170 PSTSSSGRSSQGSSTEAEPPTQPD---GAGGGGSSPSPAPATSPVPPSPSPVPTPASPSGPATLD 1231

Human  1236 FTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGM 1300
            ||||||||||||||||||||||||||||||||||||||||||.|||.||.|||||||||||||||
Mouse  1232 FTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDSGLGPGAPPGPRLRHSKSIDEGM 1296

Human  1301 FSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLAL 1365
            |||||||||||.||..|||.|.||||||||.|.||||||||||||||||||||||||||||||||
Mouse  1297 FSAEPYLRLESGGSSGGYGAYAAGSRAYGGSGSSSAFTSFLPPRPLVHPLTGKALDPASPLGLAL 1361

Human  1366 AARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHH------HSPHAHHEPVLRLWGASPPDPA 1424
            ||||||||||||||..||||||||||||:|||||.||      |||||.|||||||||    |||
Mouse  1362 AARERALKESSEGGVTPQPPPRPPSPRYDAPPPTLHHHSPHSPHSPHARHEPVLRLWG----DPA 1422

Human  1425 RRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAA 1489
            |||||||||||||||:|.|||||||||||||||||||||||||||||.|||.|||||||.||:||
Mouse  1423 RRELGYRAGLGSQEKALTASPPAARRSLLHRLPPTAPGVGPLLLQLGPEPPTPHPGVSKAWRTAA 1487

Human  1490 PEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLV 1554
            ||||||||||||||||||.|.|....||..:|||||||||||||.:|.||||||.:|||||||||
Mouse  1488 PEEPERLPLHVRFLENCQARPPPAGTRGSSTEDGPGVPPPSPRRVLPTSPTSPRGNEENGLPLLV 1552

Human  1555 LPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVA 1619
            ||||||||||:||||||.||||||||||||||||||||||||||||||.|:||||||..||||||
Mouse  1553 LPPPAPSVDVDDGEFLFAEPLPPPLEFSNSFEKPESPLTPGPPHPLPDPPSPATPLPAAPPPAVA 1617

Human  1620 AAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIE 1684
            |||||||||||||||||||||||||||.||||||..|||||||||||.|||||||||||||||||
Mouse  1618 AAPPTLDSTASSLTSYDSEVATLTQGAPAAPGDPPAPGPPAPAAPAPPAPQPGPDPPPGTDSGIE 1682

Human  1685 EVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSS 1749
            ||||||||||||||||||||||||||||||:.||..|.|||||||.||||||||||||||||||.
Mouse  1683 EVDSRSSSDHPLETISSASTLSSLSAEGGGNTGGVAGGGAGVASGTELLDTYVAYLDGQAFGGSG 1747

Human  1750 TPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGP 1814
            ||||||||||||||||||||||.||.|||||||||||||||||||||||||||||||||.|||||
Mouse  1748 TPGPPYPPQLMTPSKLRGRALGTSGNLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALSACSGP 1812

Human  1815 PTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASII 1879
            .||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
Mouse  1813 STAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLSQPQASALATVKASII 1877

Human  1880 SELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKP 1944
            ||||||||||||:|.||||||||||||||..|||||||||:|||||||||||||:|||:||||||
Mouse  1878 SELSSKLQQFGGASTAGGALPWARGGSGGSTDSHHGGASYIPERTSSLQRQRLSEDSQTSLLSKP 1942

Human  1945 VSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSP 2009
            .||:|||||||||||||||:|||.:.|||||||||||||:|.|||||||||||||||||||||||
Mouse  1943 SSSIFQNWPKPPLPPLPTGSGVSSSTAAAPGATSPSASSASASTRHLQGVEFEMRPPLLRRAPSP 2007

Human  2010 SLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLG 2074
            ||||||:||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Mouse  2008 SLLPASDHKVSPAPRPSSLPILPSGPLYPGLFDIRSSPTGGAGGSADPFAPVFVPPHPGISGGLG 2072

Human  2075 GALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPA 2139
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse  2073 GALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLSEHRAQFLDHEIDGSHLPA 2137

Human  2140 LTKEDYVDLGVTRVGHRMNIDRALKFFLER 2169
            ||||||||||||||||||||||||||||||
Mouse  2138 LTKEDYVDLGVTRVGHRMNIDRALKFFLER 2167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHANK1	XP_011525315.1	FERM_F0_SHANK1	70..158	CDD:340695	87/87 (100%)
		ANKYR	166..407	CDD:440430	238/240 (99%)
		ANK repeat	212..244	CDD:293786	31/31 (100%)
		ANK repeat	246..277	CDD:293786	30/30 (100%)
		ANK repeat	279..344	CDD:293786	63/64 (98%)
		ANK repeat	346..377	CDD:293786	29/30 (97%)
		SH3	557..608	CDD:473055	49/50 (98%)
		PDZ_SHANK1_3-like	656..757	CDD:467228	100/100 (100%)
		SAM_Shank1,2,3	2102..2167	CDD:188905	63/64 (98%)
Shank1	NP_001029287.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		57/61 (93%)
		FERM_F0_SHANK1	70..158	CDD:340695	87/87 (100%)
		ANKYR	166..407	CDD:440430	238/240 (99%)
		ANK repeat	212..244	CDD:293786	31/31 (100%)
		ANK 1	212..242		29/29 (100%)
		ANK repeat	246..277	CDD:293786	30/30 (100%)
		ANK 2	246..275		28/28 (100%)
		ANK repeat	279..311	CDD:293786	30/31 (97%)
		ANK 3	279..309		28/29 (97%)
		ANK repeat	313..344	CDD:293786	30/30 (100%)
		ANK 4	313..342		28/28 (100%)
		ANK repeat	346..377	CDD:293786	29/30 (97%)
		ANK 5	346..375		27/28 (96%)
		ANK 6	379..407		27/27 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..432		17/18 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..546		87/91 (96%)
		SH3	557..608	CDD:473055	49/50 (98%)
		PDZ_SHANK1_3-like	656..757	CDD:467228	100/100 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	841..894		50/52 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	917..1233		289/319 (91%)
		PRK07764	<947..1156	CDD:236090	186/209 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1245..1290		41/44 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1308..1331		15/22 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1361..1417		44/55 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1429..1458		26/28 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1500..1725		195/224 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1740..1790		46/49 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1828..1866		36/37 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1898..1988		76/89 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2002..2029		25/26 (96%)
		SAM_Shank1,2,3	2100..2165	CDD:188905	63/64 (98%)