Protein Alignment SHANK1 and shn-1

DIOPT Version :10

• Sequence 1: XP_011525315.1
• Gene: SHANK1 / 50944
• HGNCID: 15474
• Length: 2169
• Species: Homo sapiens
• Sequence 2: NP_001379494.1
• Gene: shn-1 / 174739
• WormBaseID: WBGene00006444
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 1233
• Identity: 347/1233 - (28%)
• Similarity: 493/1233 - (39%)
• Gaps: 351/1233 - (28%)

Human    76 RIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLRE 140
            :|.:|:|:..|.|....:..||..|:::|..|.::|....|||||.|...||...||.|:|.:|:
 Worm    11 QIFVPELNVRKFLAVTQNDFIWDVKRKLLATLPQALPQAFNYGLFLPPCDGRAGKFLLEDRTIRD 75

Human   141 YPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDP 205
            ||  |...|||||.:||.||||..|||||||..:|||..||||::|||...::||.::..:|||.
 Worm    76 YP--FTDCVPYLELKYKKRVYKMLNLDEKQLKAMHTKGQLKKFMDYVQQKNNEKVEKMCSQGLDA 138

Human   206 NYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG 270
            |:||: .|||||||||....:..||.:|..||||:|||..:|.||:||||.......:..|::||
 Worm   139 NFHDA-QGETPLTLAAGIPNNRAVIVSLIGGGAHVDFRNSEGQTAMHKAAFLSSFENVKTLIELG 202

Human   271 GSPNYKDRRGLTPLFHTAMVG-GDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLL 334
            .||||:|..|||||::..:.. .:.:..|:||...|.:|:.|.:|..||||||:.|.::|:||||
 Worm   203 ASPNYRDPIGLTPLYYNMLTADSNDQVAEILLREAADIGVTDMHGNHEIHQACKNGLTKHVEHLL 267

Human   335 FYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELI 399
            ::|.:..|:|.:||:.||:||:.|:..|||:||:||||....|..|||...|:.|.||..:.:::
 Worm   268 YFGGQIDAENVNGNSPLHVCAVNNRPECARVLLFRGADHLAVNKQGQTALHVSHIVGNPGVADVV 332

Human   400 RNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGP 464
            :.|..:..||::.:|:|:.|||      |:......|:.|.:|:...|  |:..|
 Worm   333 QAHNPKSSVPYRGTPQYSTRRR------LSSTITRRRSMSQSSICSQD--VYRTP---------- 379

Human   465 TSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAG 529
                  ||        :..|.:.:|.||      ||||.......       ||..||.|.
 Worm   380 ------QS--------VRKGPMSAAPSP------SPSRSSRTTIT-------PSEYGTMRR---- 413

Human   530 GTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEG 594
             :|.....||.:.:.|....:                              .::|.|..|
 Worm   414 -SGMDSMRGGGMIAAGHETNI------------------------------ARILVIPRG----- 442

Human   595 QVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYII 659
             ||
 Worm   443 -VK-------------------------------------------------------------- 444

Human   660 KEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIE 724
                         ||||:|||||.......|.||...||||:.|.||..|:|.|||||.||:|:|
 Worm   445 -------------GFGFILRGAKHVAMPLNFEPTAQVPALQFFEGVDMSGMAVRAGLRPGDYLLE 496

Human   725 VNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEA---VHKKAPQQAKRLPPPTISLRS 786
            ::|.:|.:..|.:||..|:|.|:|:.:||:.|. ..||...   ||:          |||.|.|.
 Worm   497 IDGIDVRRCSHDEVVEFIQQAGDTITLKVITVD-VADMSRGGTIVHR----------PPTASSRH 550

Human   787 KSMTSELEEMVSPWKKKSEYEQQPAPVPSMEKKRTVYQMALNKLD----------EILAAAQQTI 841
            ..:                :...|:.:.|..|..:||:|..:..|          ||..|..::.
 Worm   551 SLV----------------FTPTPSAIYSSTKASSVYRMRFDTHDAHGVDYYAPNEIRNAYSESR 599

Human   842 SAS--ESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAED 904
            .||  :.||.|...|          |.|.......:..||.:...:     .:...|:|:.....
 Worm   600 HASVRQRPGSGRRIS----------AAELENLMVRQRVPSVQGSPY-----QMQYDQESLNGGYS 649

Human   905 DRPYLAPPAMK--------FSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPS-PRGG 960
            .:.|.:...||        .:.|..:..|......||||..|  |      :.|.|.||. .|..
 Worm   650 SKKYNSVSDMKRRKGQRNVVASSAGLNRSTFEQAAPTTSTFE--Y------NCSSRSTPQLSRMD 706

Human   961 PFNP-GSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHH 1024
            .|:. .....:||..|||:  .||...|..|.::|.|.....|.:....|       |||.|..|
 Worm   707 SFDSFDDEDEMPAPPPASY--ISPDLQRDSSMQRSEYSRPFRPTSRPKTP-------PPPPPMQH 762

Human  1025 HAHPPHPPEMETGGSPDDPP-PRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGP 1088
            ..|..|..:.:      .|. ||.|..||| ::..:...|.|.|..|
 Worm   763 QNHQNHQYQQQ------HPSLPRSASTPQP-IQQQQSSIPPPPPPPP------------------ 802

Human  1089 ALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPAS---PQPPP 1150
                   ||......::                  ||..|.....:||.|.|..|.|   |.|||
 Worm   803 -------PPHCEPTMVH------------------VEFTPPSTSSVPPPPPPLPPISSGAPPPPP 842

Human  1151 AVAAPSEKNSIPIPT-----IIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAP 1210
                       |.|.     :...||...|   :|:|.|.:|....|.:..
 Worm   843 -----------PPPPGGLMHVAASAPVLMS---NSKGISADALKSVQLKKA-------------- 879

Human  1211 AMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDE 1273
              .|...|.:.|....:.:..:|.||......||             |:|||.:....|..:|
 Worm   880 --EPRETSAASVSNNNNNNNNSTTDFQMDLKNAL-------------AKRRSKVAHDVDEDEE 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHANK1	XP_011525315.1	FERM_F0_SHANK1	70..158	CDD:340695	33/81 (41%)
		ANKYR	166..407	CDD:440430	110/241 (46%)
		ANK repeat	212..244	CDD:293786	18/31 (58%)
		ANK repeat	246..277	CDD:293786	14/30 (47%)
		ANK repeat	279..344	CDD:293786	26/65 (40%)
		ANK repeat	346..377	CDD:293786	16/30 (53%)
		SH3	557..608	CDD:473055	5/50 (10%)
		PDZ_SHANK1_3-like	656..757	CDD:467228	41/100 (41%)
		SAM_Shank1,2,3	2102..2167	CDD:188905
shn-1	NP_001379494.1	FERM_F0_SHANK	8..91	CDD:340611	33/81 (41%)
		ANKYR	95..336	CDD:440430	111/241 (46%)
		ANK repeat	145..176	CDD:293786	18/30 (60%)
		ANK repeat	178..209	CDD:293786	14/30 (47%)
		ANK repeat	211..277	CDD:293786	26/65 (40%)
		ANK repeat	279..310	CDD:293786	16/30 (53%)
		PDZ_SHANK1_3-like	429..529	CDD:467228	46/210 (22%)
		SAM_Shank1,2,3	1074..1139	CDD:188905