Protein Alignment PDE11A and Pde6

DIOPT Version :10

• Sequence 1: NP_058649.3
• Gene: PDE11A / 50940
• HGNCID: 8773
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Alignment Length: 950
• Identity: 381/950 - (40%)
• Similarity: 537/950 - (56%)
• Gaps: 101/950 - (10%)

Human    48 ALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCG------------------ 94
            |...:|...|.:..|.||..||.:.|...||...|    :|.....|
  Fly    30 ASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGA----IPASSSSGNQVKLEHHHRQSNNNRPA 90

Human    95 --------------GVPLSPSWAGGSRGDGNLQRRASQKE-LRK---SFARSKAIHVNRTYDEQ- 140
                          |...||| ...|:...::|.:.||:: |.|   :.::.....|.|.::|:
  Fly    91 VTNRSSETKLMTPTGSSSSPS-QSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKP 154

Human   141 ------VTSRA-QEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAI-------- 190
                  :|.|| .|.||.::.....||....|..|:.:....:.:...:.:..|.::
  Fly   155 EAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSL 219

Human   191 -DYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLV 254
             :.:.||...:|.:.|:||::|::|:||:..|.:|||:.|.|:..|||.||||.:|... .|.||
  Fly   220 PECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPT-NKYLV 283

Human   255 SKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYK 319
            :|.|||...|.|....:..::.|:.:|:|.||.|.|.:..:.:||.:||:|.|||.|||..||||
  Fly   284 AKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYK 348

Human   320 TKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384
            |.::|||||.:.:|:||||||.|||......|.|.|.::.:.||.||||.|.|||||..|.:||.
  Fly   349 TNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYR 413

Human   385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE-----------DIESP---- 434
            |::.||.:...:||||.:||.:|.|||..|:.|||||||||.|::           .||.|
  Fly   414 RNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPA 478

Human   435 --VVKFTKSFE----------LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVN 487
              .:|...|||          |........|.|..:.|:.:.|.|...   .||:.||:||..||
  Fly   479 TRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLA---QIAQFVATTGQTVN 540

Human   488 ISDA------YQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRL 546
            |.|.      :...|.:.|.|.     .:::||:||.|:..::|||||::|:.:|.||.|:|..:
  Fly   541 ICDVIEWVRDHNQIRAEDEIDS-----TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASI 600

Human   547 FEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDI 611
            ||||.|||||||:||.||:...|..|||.|||:.||||||.|:.:.:|.....|.......:...
  Fly   601 FEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSF 665

Human   612 HFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLM 676
            .|.||.|..|....|.|||||:..:|.:|:|.|:.||||:|:||||||.|.|||||||.||.|.|
  Fly   666 TFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTM 730

Human   677 FAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHA 741
            ||||.|...:..:|::|||.::|.||||||||||||||||.|:.|.||.|| |::|:|||||:..
  Fly   731 FAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTMEHHHFDQC 794

Human   742 VMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDI 806
            ||||.|||:|||..||.::|..:|:.::.:||:|||.:||::|..|.|||..||:||..:..:|:
  Fly   795 VMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDL 859

Human   807 FRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 871
            ...|:|||||:.|:.||||:..:||:||..|||:|||.|:|:|...|.|:.||.||||||::|:.
  Fly   860 LCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVG 924

Human   872 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
            :||.||:|||:.|......:.|:.:....||..|::|.:|
  Fly   925 FIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEK 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..125		24/112 (21%)
		GAF	217..380	CDD:214500	77/162 (48%)
		GAF	402..568	CDD:214500	74/198 (37%)
		PDEase_I	663..898	CDD:459723	125/234 (53%)
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	76/159 (48%)
		GAF	431..619	CDD:214500	73/195 (37%)
		PDEase_I	717..950	CDD:459723	125/233 (54%)