Protein Alignment PDE11A and Pde1c

DIOPT Version :10

• Sequence 1: NP_058649.3
• Gene: PDE11A / 50940
• HGNCID: 8773
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Alignment Length: 1031
• Identity: 226/1031 - (21%)
• Similarity: 365/1031 - (35%)
• Gaps: 285/1031 - (27%)

Human    43 SQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGG-- 105
            |.|.|:.|      |||..|.|:    ||.|||.. :|:|.....|..|...|...:...|||
  Fly   169 SGGPGSSG------GTSGAATSS----SSSGGGAA-SGAASGSVGPASGTATGTGSASGGAGGVS 222

Human   106 --------------------SRGDGNLQRRASQKELRKSFARSKAIHVNRT-YDEQVTSR----- 144
                                :..:|.:.|..|...:|::.:|      |.| :|.|:.|.
  Fly   223 TPAQEAASPTVSELSGSGSNATINGQVARHGSLTIIRRTNSR------NFTQFDGQLASPSSTAC 281

Human   145 ---------AQEPLSSVRRRAL----------------LRKASSLPPTTAHILSALLESRVNLPR 184
                     ||.|||......|                .|.::..|..:....||    .|.:..
  Fly   282 SSTAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASA----AVKMQP 342

Human   185 YPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAG 249
            ..|.|.:|                   :::::.::|.:......|.....||..::..: ....|
  Fly   343 SSPNATNY-------------------LADNIQISSANLSQTEMVVGRDSADYTAMHSI-NVGVG 387

Human   250 KKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDK 314
            ...|        .|...:|   .|:.:..:.|   ..:.:.....:|.::|.....    |.::|
  Fly   388 NSFL--------RGDTDIP---QESGHSFETP---SNMSFTAGQWDTESLPPVDTP----DALNK 434

Human   315 LTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAI--------- 370
            ..| :.:|||    |..|.|.:..              ||    ||..|.:....:
  Fly   435 AAG-RIRSLL----RRMDHETVAY--------------ED----MQRNLHYAARVLEAVFIDESR 476

Human   371 ----SNAQLFAASRKEY------------ERSRALLEV--------VNDLFEEQTDLEKIVKKI- 410
                .|.:....||..:            .||.:|.|.        |....:.|..:|...|.:
  Fly   477 EGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVS 541

Human   411 ----MHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLI 471
                .|...|.......|    |.|..|..|...:.|.:  :.|...|:..|:..:|.....
  Fly   542 QAPQTHSGPTGPPSNTSS----ETIAQPAPKLQPALETV--RESVMEESPSKDPGDKGPPPP--- 597

Human   472 NNSIAELVASTGLPVNISDAYQDPRFDAEADQI------------SGFHIRSVLCVPIWNSNHQI 524
             .|.:.|.:.|   ...|.|..:|...|...|.            :..|.:..|..|.|..:
  Fly   598 -ASTSTLTSQT---TTSSSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARS--- 655

Human   525 IGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVK---KSWAKQSVALDVLSYHAT 586
              ::....||     .|.|..|.|             :..|.|.   :.|...:....:    ||
  Fly   656 --MSTNKTRL-----ADEDDELSE-------------VQPDAVPPEVREWLASTFTRQM----AT 696

Human   587 CSKA--EVDKFKAANIPLVSELAIDDIH---------------------FDDFSLDVDAMITA-- 626
            ..:.  |..||::....:.:.:.:|.::                     .||::.||.|:..|
  Fly   697 SRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAAS 761

Human   627 -------ALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL--YHNWRHAFNVCQLMFAMLTT 682
                   |..:|...|.:.||||....|..:|..|.:.|....  |||..||.:|.|.:...|..
  Fly   762 GQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCN 826

Human   683 AGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQS 747
            .|..:.||::||.|.::..|.||.:|.||.|.|...|||..|.||...|.||:||.:.:..:|:.
  Fly   827 TGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLRE 891

Human   748 EGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLM 812
            :.:||.::||.:|:.:|..|:.:.:|.||:|.:|::.....:|::..|.  .|...:.:  |:::
  Fly   892 DEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEA--TIDKQKVL--SLVL 952

Human   813 TACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSIC 877
            ..||:....|.|.:..:...|:..|||.|||.|: ||.|..|.:.||| ...:...|:.:||.|.
  Fly   953 HCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK-ELGLPFSPLCDRN-NTLVAESQICFIDFIV 1015

Human   878 MP----LYQALVKVNVKLKPMLDSVATNRSKWEEL--HQKRLLASTASSSPASVMV 927
            .|    :...|..:...:.||      |:||...|  |:     :||:|:..|.:|
  Fly  1016 EPSMGVMSDMLELILAPIAPM------NKSKPATLVEHE-----TTANSTTNSAIV 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..125		26/103 (25%)
		GAF	217..380	CDD:214500	27/175 (15%)
		GAF	402..568	CDD:214500	33/182 (18%)
		PDEase_I	663..898	CDD:459723	77/238 (32%)
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	14/81 (17%)
		PDEase_I	807..1027	CDD:459723	74/225 (33%)