Protein Alignment PDE11A and dnc

DIOPT Version :10

• Sequence 1: NP_058649.3
• Gene: PDE11A / 50940
• HGNCID: 8773
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 963
• Identity: 202/963 - (20%)
• Similarity: 331/963 - (34%)
• Gaps: 323/963 - (33%)

Human    49 LGPRPSLAGTSS------------LAHSTCRGG--------SSVGGG-----TGPNGSAHSQPLP 88
            |.|..|..|:||            ||.|:..||        |||...     |..:.||.:...|
  Fly   420 LAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHP 484

Human    89 GGGDCGGVPLSPSWA-GGSRGDGNLQRRASQ--KELRKSFARSKAIHVNRTYDEQVTSRAQEPLS 150
            .....  :|.|...| .||.||  ||:..|:  |..|.:.|       |..:|.:....|:.||.
  Fly   485 SNSQL--LPTSKMQAEQGSIGD--LQKYHSRYLKNRRHTLA-------NVRFDVENGQGARSPLE 538

Human   151 SVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFL-------EL 208
            ..            .|:...:|.       |||:                .|:.||       |:
  Fly   539 GG------------SPSAGLVLQ-------NLPQ----------------RRESFLYRSDSDFEM 568

Human   209 -VKDISNDLDLTSLSYK-----ILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLL 267
             .|.:|.:..:.|..:|     ||:        ||         :.|:..:|:.|..:     |.
  Fly   569 SPKSMSRNSSIASERFKEQEASILV--------DR---------SHGEDLIVTPFAQI-----LA 611

Human   268 PCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSD 332
            ...|..| |.:.:                .|:|.:.:.||                   |.:||.
  Fly   612 SLRSVRN-NLLSL----------------TNVPASNKSRR-------------------PNQSSS 640

Human   333 GEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLF 397
            ....|       .|.|||.::.:|                               |...:..|..
  Fly   641 ASRSG-------NPPGAPLSQGEE-------------------------------AYTRLATDTI 667

Human   398 EE-QTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESM 461
            || ...|:::.....||:             :.|:.|  :||.:   :::.:.|     .|.||.
  Fly   668 EELDWCLDQLETIQTHRS-------------VSDMAS--LKFKR---MLNKELS-----HFSESS 709

Human   462 EKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFD-----------------AEADQISGFHI 509
            ..        .|.|:|.:.||.|     |..|:  ||                 |...|.:|.:.
  Fly   710 RS--------GNQISEYICSTFL-----DKQQE--FDLPSLRVEDNPELVAANAAAGQQSAGQYA 759

Human   510 RSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCG-----LGIN-------NTI 562
            ||  ..|......||.||.:.|:..:.                |.|     .|:.       .|:
  Fly   760 RS--RSPRGPPMSQISGVKRPLSHTNS----------------FTGERLPTFGVETPRENELGTL 806

Human   563 MYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAA 627
            :.:  ..:|..|..::...|               .|.||.                     ..|
  Fly   807 LGE--LDTWGIQIFSIGEFS---------------VNRPLT---------------------CVA 833

Human   628 LRMFMELGMVQKFKIDYETLCRWLLTVRKNY-RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 691
            ..:|....::....|..:|...::.|:..:| :...:||..||.:|.|....:|.|...:.:.|.
  Fly   834 YTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTP 898

Human   692 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANL 756
            :|:...:.....||:||.|..|.|...|.|.||.:|...:.||:||...|..:||::|.:||.|:
  Fly   899 LEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNM 963

Human   757 SSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS----KGEYDWNIKNHRDIFRSM--LMTAC 815
            ..|:...|.:::...:|:||::.:.....:...:|.    .|.....:.|:.|..:.:  |:...
  Fly   964 QKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCA 1028

Human   816 DLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPL 880
            ||...|||..:.::...|:..|||.|||:|| |..:..|.:.||:.. .:.:.|:.:||.|..||
  Fly  1029 DLSNPTKPLPLYKRWVALLMEEFFLQGDKER-ESGMDISPMCDRHNA-TIEKSQVGFIDYIVHPL 1091

Human   881 YQALVK-VNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDR 932
            ::.... |:...:.:||::..||..::.:.......|....:|      :|||
  Fly  1092 WETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENP------QEDR 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..125		30/103 (29%)
		GAF	217..380	CDD:214500	26/167 (16%)
		GAF	402..568	CDD:214500	36/194 (19%)
		PDEase_I	663..898	CDD:459723	70/241 (29%)
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	40/236 (17%)
		PDEase_I	870..1110	CDD:459723	70/241 (29%)