Protein Alignment PCBP2 and HnRNP-K

DIOPT Version :10

• Sequence 1: NP_005007.2
• Gene: PCBP2 / 5094
• HGNCID: 8648
• Length: 366
• Species: Homo sapiens
• Sequence 2: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 492
• Identity: 107/492 - (21%)
• Similarity: 168/492 - (34%)
• Gaps: 185/492 - (37%)

Human    15 TIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAG---PTNAIFKAFAMII 76
            |:|:|:.....|::|||.|:.::|||.:..|.:::.:...|||.|.::.   .|..|........
  Fly    30 TVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQGPERTIQISADIESTLEIITEMLKYF 94

Human    77 DKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQ-VQVAGDMLPN 140
            ::.:||..               :||::..|..|.:|||||.||||||:..|.: ::|..::.|.
  Fly    95 EERDEDFD---------------VRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQ 144

Human   141 STERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSD 205
            ||:|.:...|....:||.|:::..:..:|    |.||....|  .|.:...::|.....|.|||.
  Fly   145 STDRVVQTVGKQSQVIEAVREVITLTRDT----PIKGAIHNY--DPMNFDRVYADEYGGYGTGSG 203

Human   206 SASFPHTTPSM------------------------------------------------------ 216
            |     |.||.
  Fly   204 S-----TRPSQRGNNRNGGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGAAGGAVAGA 263

Human   217 --------CLNP-------DLE------------------------------------GPPLEAY 230
                    .:||       |::                                    |.|.:..
  Fly   264 GMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFAGNSFGGGAGGPFGGGSFGNNGFGGGPSDFG 328

Human   231 TIQGQYAIPQ-----PDLTKLHQLAMQQSHFPM-------------------------------T 259
            ...|.:...|     |.|....|.....|..|.                               .
  Fly   329 GNSGNFGQAQGTNSLPSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGA 393

Human   260 HGNTGFSGIESSSPEVKGYWAGLDASAQT---------TSHELTIPNDLIGCIIGRQGAKINEIR 315
            :|..||:.:..::....|     ..:|.|         .|.::|||.:|.|.|||:.|.:|..||
  Fly   394 NGAGGFNAVGGANGGPNG-----SPNAATNVPQGHDPNNSTQVTIPKELAGAIIGKGGGRIRRIR 453

Human   316 QMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLI 352
            ..|.|.|.|..|:..|.||.:||:|:...|.:||||:
  Fly   454 NESSAYITIDEPLPNSNDRIITISGTPKQIQMAQYLL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCBP2	NP_005007.2	KH-I_PCBP1_2_rpt1	13..82	CDD:411943	18/69 (26%)
		KH-I_PCBP1_2_rpt2	92..169	CDD:411946	25/77 (32%)
		KH-I_PCBP1_2_rpt3	285..360	CDD:411949	31/77 (40%)
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	18/60 (30%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	26/84 (31%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	29/65 (45%)