Protein Alignment PC and PCB

DIOPT Version :10

• Sequence 1: NP_000911.2
• Gene: PC / 5091
• HGNCID: 8636
• Length: 1178
• Species: Homo sapiens
• Sequence 2: NP_724841.1
• Gene: PCB / 36020
• FlyBaseID: FBgn0027580
• Length: 1197
• Species: Drosophila melanogaster
• Alignment Length: 1192
• Identity: 800/1192 - (67%)
• Similarity: 964/1192 - (80%)
• Gaps: 36/1192 - (3%)

Human    16 IRRTSTAPAASPNVR-----------RLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSE 69
            :|:|      .|.||           ::|||||:.|:||||||||||||||||||||::||:|||
  Fly    13 LRKT------QPRVRLNAIFKNGYSSKVEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSE 71

Human    70 QDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDA 134
            ||...||||||||:|::|:||.||:|||:||::|:|.|||:||||||||||||||:|||||..||
  Fly    72 QDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDA 136

Human   135 GVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGG 199
            |:||||||||||:||||||.||..||.||||:|||||.|:|:..||.||...:|.|:||||||||
  Fly   137 GLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGG 201

Human   200 GGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERD 264
            ||||||||...|::||::.||.|||.|||||||:|:|||||:|||||||:|||:.||::||||||
  Fly   202 GGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERD 266

Human   265 CSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRL 329
            ||:|||||||||||||..|..::|.::|..:|:||:.||||||||||||.|..|..||||||:||
  Fly   267 CSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVNARL 331

Human   330 QVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRI 394
            |||||||||||.:|||.:||.||||.:||:||..|:.|...|.||||||||||||..|||:|||:
  Fly   332 QVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRL 396

Human   395 EVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNI 459
            ||||||||||||||:|||:.||:|||:|||||||||:|..|..::|:||:|||.|||:|||||||
  Fly   397 EVFRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNI 461

Human   460 AFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSP 524
            .||.|||.||:||.|.:||.||||:|:||:.:|:.|||||||:|:|.|:||||.||:.....|:.
  Fly   462 PFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPAL 526

Human   525 TDPVVPAVP-----------------IGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRD 572
            ..|.||.||                 :..||.|.|::|:.||||.||:.|||...||||||||||
  Fly   527 VSPHVPEVPLDLSPEAIEREERGEAKVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRD 591

Human   573 AHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNI 637
            |||||||||||:|||.||:|||.|.|:.|:|:|||||||||||:|||:||||.||:|:|:.||||
  Fly   592 AHQSLLATRVRSHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNI 656

Human   638 PFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEA 702
            |||||||||||||||:||||||:||||:|.:.|||:||||||||||||::|||||||.|||||||
  Fly   657 PFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEA 721

Human   703 AISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLP 767
            ||||||||:||.||||.|:||..||:|||:||||:||||||||||||.:..:|::::||:.||:|
  Fly   722 AISYTGDVSDPKRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIP 786

Human   768 LHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVF 832
            :|||||||||||||:|||||.|||||||||.||||||||||||||:||..:||||||.:.:..|.
  Fly   787 IHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVS 851

Human   833 DYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEA 897
            :||.|||..|.|||.|:||.||:|||:|||.|||||||||||.|||.|:|||..|::|||||.||
  Fly   852 EYSAYWEQTRTLYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREA 916

Human   898 NQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEP 962
            |.:|||:||||||||:|||||||||||.|:..:...:|||||||:||||:|||.||:||||||||
  Fly   917 NLLLGDIIKVTPSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEP 981

Human   963 FRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATF 1027
            .||:||||:||:||||||.|..||...|:|||.:.| ..||..||:|||:||.|...|.:|...:
  Fly   982 LRSRVLKDMPRIEGRPGAELKDLDFDKLKKELQESH-TCVTNRDVMSAALYPQVTNDFLNFREKY 1045

Human  1028 GPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVS-DLNRAGQRQVFFELNGQLRSILVKD 1091
            ||:|.|:||:||.|||:.|||:|.|||||||.:|||||| ||...|.|:||||||||||::.:.|
  Fly  1046 GPVDKLDTRIFLTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILD 1110

Human  1092 TQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGT 1156
            .:|:||:|.||||.|..|.::||||||.||||:|..|.||.|||||.||||||||.||.||:.|.
  Fly  1111 KEAVKEIHVHPKANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGV 1175

Human  1157 VRKVHVTKDMTLEGDDLILEIE 1178
            |:|:.:.....|||:|||:.||
  Fly  1176 VKKLEIANGTKLEGEDLIMIIE 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PC	NP_000911.2	PycA	35..1177	CDD:440660	791/1159 (68%)
PCB	NP_724841.1	PycA	37..1196	CDD:440660	791/1159 (68%)