DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment F11R and kirre

DIOPT Version :9

Sequence 1:	NP_001369656.1	Gene:	F11R / 50848	HGNCID:	14685	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	71/307 - (23%)
Similarity:	103/307 - (33%)	Gaps:	89/307 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    10 KLLCLFILAILLCSLALGSVTVH-------SSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQ- 66
            :||.|.::.:|:.:|.|..:.||       ||:.......::....|.:.||.||.......|:
  Fly     8 RLLVLPLILVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAASSANDES 72

Human    67 ----GDT--TRLVCYNNKITASYEDRVTFLPTGITFK----SVTREDTG-----------TYTCM 110
                ||.  ..........||....||| ||..:..|    ..|::|.|           .|:.:
  Fly    73 KPKGGDNGGQHFAMEPQDQTAVVGSRVT-LPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMV 136

Human   111 VSEEGGN-----------------------SYGEVKV-----KLIVLVPPSKPTVNIPSSATIGN 147
            .|:|.|:                       ..||..:     ||.|||||..|.:      |.|:
  Fly   137 GSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKI------TQGD 195

Human   148 RAVLT--------CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGE-------- 196
            ..|.|        |..|.|.|.:|.||. ||:       .........||..|....
  Fly   196 YLVTTEDREIELECVSQGGKPAAEITWI-DGL-------GNVLTKGIEYVKEPLADSRRITARSI 252

Human   197 LVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAV 243
            |...|........::|:|:|.......|..:.:| |:....|||:.|
  Fly   253 LKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLE-VKYAPKVIVSVV 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
F11R	NP_001369656.1	IgV_1_JAM1-like	30..129	CDD:409538	31/155 (20%)
		Ig strand B	46..50	CDD:409538	0/3 (0%)
		Ig strand C	59..63	CDD:409538	0/3 (0%)
		Ig strand E	92..96	CDD:409538	0/3 (0%)
		Ig strand F	106..111	CDD:409538	1/4 (25%)
		Ig strand G	121..124	CDD:409538	1/2 (50%)
		IgI_2_JAM1	135..231	CDD:409542	23/111 (21%)
		Ig strand B	149..153	CDD:409542	2/11 (18%)
		Ig strand C	163..167	CDD:409542	2/3 (67%)
		Ig strand E	195..199	CDD:409542	1/11 (9%)
		Ig strand F	209..214	CDD:409542	1/4 (25%)
		Ig strand G	224..227	CDD:409542	1/2 (50%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	19/96 (20%)
		IG_like	88..182	CDD:214653	19/94 (20%)
		C2-set_2	189..279	CDD:285423	22/103 (21%)
		Ig_2	307..379	CDD:290606
		I-set	382..462	CDD:254352
		IGc2	396..446	CDD:197706
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910