Protein Alignment PAX7 and ey

DIOPT Version :10

• Sequence 1: NP_002575.1
• Gene: PAX7 / 5081
• HGNCID: 8621
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Alignment Length: 806
• Identity: 210/806 - (26%)
• Similarity: 277/806 - (34%)
• Gaps: 364/806 - (45%)

Human    38 VNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIG 102
            ||||||||:.|||||:..|.||||:||.|.|||.|||.|:||:|||||||.||.|||||||.|||
  Fly   101 VNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIG 165

Human   103 GSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLVSSISRVLRIKFGKK 167
            ||||| |||.:|..||.:||||.|.:|:||||||||::..|....:||  ||||:||||....:|
  Fly   166 GSKPR-VATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPS--VSSINRVLRNLAAQK 227

Human   168 EEEDE--------------------------------------------------------ADKK 176
            |::..                                                        |...
  Fly   228 EQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNS 292

Human   177 EDDGEKKA--------------------------------------------------------- 184
            .:..|::|
  Fly   293 GEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQ 357

Human   185 ----------------------------------------------------------------- 184
                                                                             
  Fly   358 QSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVA 422

Human   185 ------KHSIDGILGDK----------GNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELE 233
                  |..:||...|:          |...:.|:..:.:..|.||||.:|:||:||.:|::.||
  Fly   423 TEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLE 487

Human   234 KAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQ------------AGA-------- 278
            |.||||||||::.||.||.:..|.|||:|||||||||:||::            .||
  Fly   488 KEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTS 552

Human   279 ---------NQLAAFNHLLPG--GFP----------PTGM------PTL--------PPYQLPDS 308
                     |.|:|.:.||.|  |.|          |:.:      |||        .|..:| .
  Fly   553 ATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIP-H 616

Human   309 TYPTTTISQDGG------STVHRPQPL---------------------------PPSTMHQGGLA 340
            ..|:.|...|.|      ..|..|.||                           |....:.|...
  Fly   617 IRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFG 681

Human   341 AAAA-----AADTSSAYGARHSFSSYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQP 400
            |..:     |...|.:|||.....|::.|.:.|.||.:.: |....|:|..:.........||..
  Fly   682 AMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPI-PQQGDLTPSSLYPCHMTLRPPPMA 745

Human   401 QADFSISPLHG------GLDSATS--ISASCSQRADSIKPGDSLP-------------------- 437
            .|...|.|..|      ||.|..|  :.||||.....:....:||
  Fly   746 PAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSA 810

Human   438 ---------TSQAYCPPTYS---------TTGYSVDP----VAGYQYGQYGQSECLVPWASPVPI 480
                     .:|..||...|         ::|:|.||    |:.|.:..|.       :||....
  Fly   811 SANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYN-------YASSANT 868

Human   481 PSPTPR---------------ASCLF 491
            .:|:..               |||.:
  Fly   869 MTPSSASGTSAHVAPGKQQFFASCFY 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX7	NP_002575.1	paired box domain	34..164		85/125 (68%)
		PAX	34..163	CDD:238076	85/124 (69%)
		octapeptide	86..93		4/6 (67%)
		paired homeodomain	217..275		36/57 (63%)
		Homeodomain	218..274	CDD:459649	35/55 (64%)
		Pax7	347..385	CDD:403540	11/37 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..409		4/19 (21%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	83/122 (68%)
		Homeodomain	473..528	CDD:459649	35/54 (65%)