Protein Alignment PAX7 and eyg

DIOPT Version :10

• Sequence 1: NP_002575.1
• Gene: PAX7 / 5081
• HGNCID: 8621
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 164/569 - (28%)
• Similarity: 221/569 - (38%)
• Gaps: 188/569 - (33%)

Human    26 PLEVSTPLGQGRVNQLGGV-FINGRPLPNHI-----RHKIVEMAHH-GIRPCVISRQLRVSHGCV 83
            |..|..|.|.|.....||: ...|.|..:.:     :|:::|.:.. |:|...|::.:....|.|
  Fly    83 PTSVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAV 147

Human    84 SKILCRYQETGSIR-PGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRST 147
            ||:|      ||:| ||.||||||: ||||.|..|||:||||||.:|:||||:||:.:|.|..:|
  Fly   148 SKLL------GSLRPPGLIGGSKPK-VATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNAT 205

Human   148 VPSGLVSSISRVLRIKFGKKEEED----------------------------------------- 171
            .||  ||||:|:||.:..::...:
  Fly   206 APS--VSSINRILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPS 268

Human   172 ------------------EADKKEDDGEKKAKHSIDGILG---------------------DKGN 197
                              .|......|...:.|.:.|..|                     |:..
  Fly   269 ALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENR 333

Human   198 RLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQ 262
            .:|  ||...:.|.|   |.||:||||:.||||||||.|:::|||.:.|||.|:.||.|:|||||
  Fly   334 HID--SDYLDDDDEP---KFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQ 393

Human   263 VWFSNRRARWRKQAGANQL-------AAFNHLLPGGFPPTGMPT---------------LPPYQL 305
            ||||||||:||:....|.|       |...|.......|...||               :||.|.
  Fly   394 VWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSNHSSASTSAPVAPVPPPQQ 458

Human   306 PDSTYPTTTISQDGGSTVHRPQPLPPSTM--------------HQGGLAAAAAAADTSSAYGAR- 355
            |      ..:..|     |.||..|||.:              |...|....||....|.|..:
  Fly   459 P------LPLCGD-----HSPQGPPPSVLLHPLHGPPGGHHHHHPLHLPTHPAALQLLSHYHQQQ 512

Human   356 ----------------HSFSSYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSA--------- 395
                            ......|.|..||||  ||::  ..|......|::.:|||
  Fly   513 QQQQQQQHQQQQQQHHQQQQQLSPSGCNPAA--NHLS--MGGERSAFRSLVSSPSAAAFLGLARQ 573

Human   396 ---VPPQPQADFSISPLH---GGLDS---ATSISASCSQRADSIKPGDS 435
               ......|:...|.||   |||.|   .|..:.:.:|...|....|:
  Fly   574 YAVAASLTVAEEQRSRLHYSAGGLGSGGEGTGPNTNTTQSGGSTMTVDN 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX7	NP_002575.1	paired box domain	34..164		60/137 (44%)
		PAX	34..163	CDD:238076	60/136 (44%)
		octapeptide	86..93		1/6 (17%)
		paired homeodomain	217..275		40/57 (70%)
		Homeodomain	218..274	CDD:459649	39/55 (71%)
		Pax7	347..385	CDD:403540	11/54 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..409		5/31 (16%)
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197	52/105 (50%)
		Homeodomain	349..405	CDD:459649	39/55 (71%)