Protein Alignment PAX7 and gsb

DIOPT Version :10

• Sequence 1: NP_002575.1
• Gene: PAX7 / 5081
• HGNCID: 8621
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Alignment Length: 476
• Identity: 210/476 - (44%)
• Similarity: 262/476 - (55%)
• Gaps: 86/476 - (18%)

Human    24 GFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 88
            |:|.:     |||||||||||||||||||||||.:|||||..|:||||||||||||||||||||.
  Fly    14 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILN 73

Human    89 RYQETGSIRPGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLV 153
            |:|||||||||.||||||| |||||:|.:|||.|:..||:||||||.:|::.|.||:...||  |
  Fly    74 RFQETGSIRPGVIGGSKPR-VATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPS--V 135

Human   154 SSISRVLRIKFGKKEEEDEADKKEDDGEKKAKHSIDGILGDKGNRL---DEGSDVESEPDLPLKR 215
            |||||:||...|                ....||||||||.....:   ||..| ::||.:.|||
  Fly   136 SSISRLLRGSSG----------------SGTSHSIDGILGGGAGSVGSEDESED-DAEPSVQLKR 183

Human   216 KQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQ 280
            |||||||||:.:|::.||:.|.||.|||:||||||||.|.||||||||||||||||.|||....|
  Fly   184 KQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQ 248

Human   281 LAAFNHLLPGGFPPTGMPTLPPYQLPDSTYPTTTI--SQDGGSTVHRPQPLPPSTMHQ------G 337
                            :|:..|........|||:.  :.:.|.:::..|..|.|..::      |
  Fly   249 ----------------VPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGG 297

Human   338 GLAAAAAAADTSSAYGARHSFSSYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQA 402
            .:|:.:.|:.||....|.|  |........|...|..|.           |..|..|:....|.|
  Fly   298 SVASMSPASSTSGTSSAAH--SPVQTQAQQPGTGSEFMT-----------STYGVGSSNATYPSA 349

Human   403 DFSI--SPLHGGLDSATSISASCSQRADSIKPG-------DSLPTSQAYCPPTYSTTGYSVDPVA 458
            .:|:  :|       |||.....||.|.:...|       ||...:.::.||. |..|   :.::
  Fly   350 AYSMPQTP-------ATSAEQLRSQFASAAASGSHHPSTWDSYNFAGSFFPPA-SAAG---NHIS 403

Human   459 GYQYGQYGQSECLVPWASPVP 479
            ||.: |..|...::..|...|
  Fly   404 GYHH-QVDQKSSMMTTAPTYP 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX7	NP_002575.1	paired box domain	34..164		98/129 (76%)
		PAX	34..163	CDD:238076	98/128 (77%)
		octapeptide	86..93		4/6 (67%)
		paired homeodomain	217..275		43/57 (75%)
		Homeodomain	218..274	CDD:459649	41/55 (75%)
		Pax7	347..385	CDD:403540	8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..409		5/21 (24%)
gsb	NP_523863.1	PAX	19..143	CDD:128645	96/126 (76%)
		Homeodomain	186..242	CDD:459649	41/55 (75%)