Protein Alignment KCNK4 and CG42594

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Alignment Length: 403
• Identity: 93/403 - (23%)
• Similarity: 140/403 - (34%)
• Gaps: 137/403 - (33%)

Human    68 ALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFG 132
            |:|||...|           |:...||.:|.|::|||||||||.||..||:..:.||..||||..
  Fly   591 AVGGGPPHE-----------WNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTL 644

Human   133 ILLAGVGDRLGSSLRH------------GIGHI-------------------------------E 154
            :.|:..|..|....|.            ..|:.                               |
  Fly   645 VYLSSTGSILARVAREVFSKALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQE 709

Human   155 AIFLK--WHVPPEL--------------------------------------VRVLSAMLFLLIG 179
            ..:::  :|..||.                                      :.:|:.:|.....
  Fly   710 PYYVRDVFHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSM 774

Human   180 CLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWF---WILL 241
            .:::::....|...:|.|..|:.|||..::|:|:||||.:.|.  |::|.|   ..||   :|:.
  Fly   775 MIIYIVFGAAVLYRLEKWPILDGIYFCFMSLSTIGFGDMLPGL--RRESNA---TTWFCSVYIMS 834

Human   242 GLAYFASVLTTIG----NWLRVV--SRRTRAEM-------GGLTAQAASWTGTVTARVTQRAG-- 291
            |:...|.....|.    :.:|:|  .::|.|..       ||..:..|...|.....|....|
  Fly   835 GMTLTAMCFNVIHEEIVHRIRIVVEFKKTSAANSGGGLIGGGSVSGGAGGAGGSMMDVAHEEGGQ 899

Human   292 ---PAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASAL-DYPSENLAFIDESSD 352
               ||:...||.              |.....:|.|:......||:..| ||.:..|..| .:.|
  Fly   900 YYVPASXHYEKR--------------GHLYQRNPTEETLVTDTPTSLVLKDYVNHELVPI-LTMD 949

Human   353 TQSERGCPLPRAP 365
            ....|..|.| ||
  Fly   950 PNGARLAPTP-AP 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	26/53 (49%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:462301	23/84 (27%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393		22/87 (25%)
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301	28/67 (42%)
		Ion_trans_2	774..846	CDD:462301	22/76 (29%)