Protein Alignment KCNK4 and TOK1

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_012442.1
• Gene: TOK1 / 853352
• SGDID: S000003629
• Length: 691
• Species: Saccharomyces cerevisiae
• Alignment Length: 212
• Identity: 50/212 - (23%)
• Similarity: 88/212 - (41%)
• Gaps: 47/212 - (22%)

Human    91 GSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILL----------AG-------V 138
            |:|.:|....:.|:|.|::..::...::..:.::|.|:.|.|:::          :|       |
Yeast   275 GNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRV 339

Human   139 GDRLGSSLRH------GIGHIEAIFL----------KWHVPPELVRVLSAMLFLLIGCLLFVLTP 187
            ......|.:|      .:...||..|          |.|.....|.:...|.|.|:|.|
Yeast   340 EKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGAL------ 398

Human   188 TFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTT 252
              ||.:.|:||....|||..:.|.|:|:|||.    ||  :.|.:.....|.|..:....::|:|
Yeast   399 --VFKFAENWSYFNCIYFCFLCLLTIGYGDYA----PR--TGAGRAFFVIWALGAVPLMGAILST 455

Human   253 IGNWLRVVSRRTRAEMG 269
            :|:.|..:|.....::|
Yeast   456 VGDLLFDISTSLDIKIG 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	12/67 (18%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		2/4 (50%)
		Ion_trans_2	180..258	CDD:462301	23/77 (30%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393
TOK1	NP_012442.1	Ion_trans_2	253..328	CDD:462301	10/52 (19%)
		Ion_trans_2	388..462	CDD:462301	28/87 (32%)