Protein Alignment KCNK4 and CG42340

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Alignment Length: 630
• Identity: 133/630 - (21%)
• Similarity: 193/630 - (30%)
• Gaps: 279/630 - (44%)

Human     9 LLALVLLYLVSGALVFRALEQPHEQQAQREL---------------GEVREKFLRAHPCVSDQEL 58
            :|.|||||...|::||..||...|.....|.               .|:|.:.:.....:: ::|
  Fly    99 VLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWSIT-EDL 162

Human    59 GLLIKE------------VADAL-----GGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGY 106
            .:|.||            ..|.|     .....|......|:....|...|||.:|.|:||||||
  Fly   163 NILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYASAFLYSLTLITTIGY 227

Human   107 GNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLR------------------------ 147
            |.::.||..||:..:.|||.|||:..:.|:.:|:.|.:.:|
  Fly   228 GGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGPGGGASGGV 292

Human   148 ----------------HGIGHIEAIFL-KWHVPPELVRVLSAM---------------------- 173
                            .|.||.....| ::.:||.:.:...|.
  Fly   293 GSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQQAQQQQVQ 357

Human   174 ----------------LFLLIGCLL-FVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVA- 220
                            :.:.:..|| :|.:...:|..:::||.||::||...:|.|:|||:...
  Fly   358 QGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVLESLYFCFTSLGTIGFGEMAPN 422

Human   221 GADPRQDSPAYQPLVWFWILLGLAY----FASVLTTIGNWLRVVS-------------------- 261
            ||.....:.||       ||:|:|.    |:.:.|.|..|||..|
  Fly   423 GAVALYTASAY-------ILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELALVTVAVT 480

Human   262 -----RRTRAE-----------MGG----------------------LT----------AQAASW 278
                 :|..|:           .||                      ||          .|||:.
  Fly   481 PKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQAANN 545

Human   279 TGTVTARVTQRAGP-------------------------------AAPPPEKEQP---------- 302
            :|..:|  .||..|                               |.|||.:..|
  Fly   546 SGGGSA--FQRNTPIRRSTGIPEHHLEYFVPRSISEFNLSGVGDLALPPPRRYSPNMVGGGGGMG 608

Human   303 -----------------------LLPPPPCPAQPLGRPRSPSPPEKAQPPSPPT---ASALDYPS 341
                                   .|.||    |.|....:|:..::.|||.||.   ...|...|
  Fly   609 GMGMNMGGMGMNMGMGMGLPHGLQLGPP----QTLLCSAAPTVQQQQQPPPPPAQLQIVTLKPRS 669

Human   342 ENL-AFIDESSD---------TQSERGCPLPRAPRGRRRPNPPRK 376
            |.: .|.|||..         .....|.| |..|.|  .|..|||
  Fly   670 EKMVTFEDESKQAVGGGAVGGVAGGSGTP-PHCPHG--VPTTPRK 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	25/53 (47%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:462301	27/83 (33%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393		35/169 (21%)
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:462301	25/55 (45%)
		Ion_trans_2	380..453	CDD:462301	25/79 (32%)