Protein Alignment KCNK4 and galene

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 172
• Identity: 55/172 - (31%)
• Similarity: 85/172 - (49%)
• Gaps: 33/172 - (19%)

Human     9 LLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSD---------------QEL 58
            |:.||:.|.|.||.:|:.||:|||.:.:|::..:|.........:||               :.|
  Fly    44 LVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTENIWLLSDDAVVLRESDWMANVSKHL 108

Human    59 GLLIKEVADAL---GGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFC 120
            ....|::..|:   |...|.:...      |.|....:.|:|..:|||||||:::.|||.|::..
  Fly   109 ANFEKQILTAIKADGWDGDEDLRK------SQWTFAGSLFYSIIVITTIGYGHISPRTDWGKVTT 167

Human   121 IFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHV 162
            ||||:|||||..|.|:.:||.:.:|.|         ||.|.:
  Fly   168 IFYAIVGIPLMLICLSNIGDVMATSFR---------FLYWRI 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	27/53 (51%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	31/79 (39%)
		Ion_trans_2	626..706	CDD:462301