Protein Alignment KCNK4 and CG43155

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 317
• Identity: 95/317 - (29%)
• Similarity: 149/317 - (47%)
• Gaps: 75/317 - (23%)

Human     7 LALLALVLLYLVSGALVFRALEQPHEQQAQRELGEV----REKFLRAHPCVSDQEL----GLLIK 63
            :.||..:.:|...|.|:||.||:|.|.:....|.::    ||:||  |..:::.|:    .||..
  Fly    66 IGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFL--HTILNNTEVHNLDELLSF 128

Human    64 EVA-------DALGGG----AD---PETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTD 114
            |:|       .|..||    ||   ||       .:..|.:..|.|||.|::|||||||:...|.
  Fly   129 ELAKYEAAVQQAAEGGLLIVADKDFPE-------PYERWSILQAVFFSSTVLTTIGYGNIVPVTT 186

Human   115 AGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVP--PELVRVLSAMLF-- 175
            .||:|||.:||:|||....::|..|....:::        ::|.| |:|  |:....:....|
  Fly   187 GGRVFCICFALIGIPFTLTVIADWGRLFATAV--------SVFGK-HMPTKPKFTNFIGKTWFYA 242

Human   176 -LLIGCLLFVLT--PTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWF 237
             |.:|.|...|.  ...:..:.:||:..:..||..:|:||:||||.|    |::  |.|..|...
  Fly   243 ILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLV----PKK--PNYMLLCTL 301

Human   238 WILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAA 294
            :||:|||..::::..:        ||         ..|.||     |::.:.:||.|
  Fly   302 YILIGLALTSTIIELV--------RR---------QYATSW-----AKLQELSGPMA 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	26/53 (49%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:462301	23/79 (29%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393		3/10 (30%)
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	32/77 (42%)
		Ion_trans_2	<267..319	CDD:462301	20/65 (31%)