DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNK4 and twk-30

DIOPT Version :10

Sequence 1:NP_201567.1 Gene:KCNK4 / 50801 HGNCID:6279 Length:393 Species:Homo sapiens
Sequence 2:NP_492381.3 Gene:twk-30 / 185335 WormBaseID:WBGene00006682 Length:608 Species:Caenorhabditis elegans


Alignment Length:571 Identity:116/571 - (20%)
Similarity:188/571 - (32%) Gaps:186/571 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   318 SKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENNMLREEMHRRFENAPDSAKTKALQT 382
            |.|:.|.|.  |.....|:|     :..:..:.|.......:|||....|....||         
 Worm   114 SYGVVASAV--DSHTGERVA-----IKKINDVFEHVSDATRILREIKLLRLLRHPD--------- 162

Human   383 VIEMKDSKISSMERGLRD-------LEEEI-QMLKSNGALSSEEREEEMKQMEVYRSHSKFMKNK 439
            |:|:|...:....|..||       :|.:: |::|:|..|:.|              |.:|...:
 Worm   163 VVEIKHIMLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPE--------------HYQFFLYQ 213

Human   440 VEQLKEELSSKDAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIE 504
            :.:..:.:.:.:....:||.            |..|:..|.:|......|..::  |:|:.    
 Worm   214 LLRGLKYVHAANVFHRDLKP------------KNILANADCKLKICDFGLARVS--FNDAP---- 260

Human   505 VLKESLTAKEQRAAILQTEVDALR-LRLEEK-ETMLNKKTKQIQ---------DMAEEKGTQAGE 558
                        .||..|:..|.| .|..|. .:..:|.|..|.         :|...|....|:
 Worm   261 ------------TAIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSVGCIFAEMLLGKPLFPGK 313

Human   559 --IHDLKDMLDV-----KERKVNVLQKKIENLQEQLRDKEKQMSS------------LKERVKSL 604
              :|.|..|.|.     .|....:..:|.......:|.|:....|            |.||:  |
 Worm   314 NVVHQLDLMTDFLGTPPPESISRIRNEKARRYLSSMRKKQPVPFSHKFPKADPLALRLLERL--L 376

Human   605 QADTTNTDTALTTLEEALAD----------KERTIERLKEQRDRDEREKQEEIDTYKKDLKDLRE 659
            ..|..:..:|    |:||||          :|.|.:.:.:.....||:|      ..||  |:||
 Worm   377 AFDPKDRASA----EDALADPYFSGLSNSEREPTTQPISKLEFDFERKK------LVKD--DVRE 429

Human   660 KVSLLQGDLSEKEASLLDI----KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 720
               |:..::.|....:|:.    .:..|.:..||:   .|.|.....||         |:|.|..
 Worm   430 ---LIYREILEYHPQMLEEYLRGGDQLSFMYPSGV---DRFKRQFAHLE---------ENQGKPG 479

Human   721 ------------HEATLEARASPEMSDRIQQLEREISRYKDESSKAQTEVDRLLEILKEVEN--- 770
                        |.|:|.....|..:....:...::.|      :|...|...|| .:|.:|   
 Worm   480 AAGGGRSTALHRHHASLPRERVPAPNGETAEESSDVER------RAAAAVASTLE-SEEADNGGG 537

Human   771 ---------------------EKNDKDKKIAELESLTSRQVKDQNKKVANL 800
                                 .|.||:..|||.|.  :..|.:...|||:|
 Worm   538 YSARNLMKSASISGSKCIGVQSKTDKEDTIAEEED--NETVAELTDKVASL 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNK4NP_201567.1 Ion_trans_2 <88..142 CDD:462301
Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 103..108
Ion_trans_2 180..258 CDD:462301
Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 212..217
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 285..393 17/74 (23%)
twk-30NP_492381.3 Ion_trans_2 103..166 CDD:462301 15/67 (22%)
Ion_trans_2 221..298 CDD:462301 19/106 (18%)
FN3 <372..>565 CDD:442628 47/228 (21%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.