DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNK4 and twk-46

DIOPT Version :10

Sequence 1:NP_201567.1 Gene:KCNK4 / 50801 HGNCID:6279 Length:393 Species:Homo sapiens
Sequence 2:NP_741678.1 Gene:twk-46 / 180252 WormBaseID:WBGene00006696 Length:319 Species:Caenorhabditis elegans


Alignment Length:270 Identity:90/270 - (33%)
Similarity:140/270 - (51%) Gaps:32/270 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     1 MRSTTLLAL--LALVLLYLVSGALVFRALEQPHEQQAQREL-----GEVREKFLRAHPCVSDQEL 58
            ||.:.:..|  |.:.::||..||:||..:|.|.| :.:||.     .:.|::.::..  :.:.|:
 Worm    20 MRESNMRILVGLGVAVVYLFVGAIVFVRIEYPLE-KIEREAYLDYQNQWRDRLIQLD--IDESEI 81

Human    59 GLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFY 123
            ..|...:.:|...|...:.|.||:.:   |..|.||||:||:|:|:|||.|:.||:.|:||.|.|
 Worm    82 DKLFLNIREAALNGIWMDRNLTSDPN---WTFGQAFFFAGTLISTVGYGRVSPRTEYGKLFTILY 143

Human   124 ALVGIPLFGILLAGV-------GDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCL 181
            .::||||...||:.:       ..:|...|...:||   :|...|:....|.|:.|.|      |
 Worm   144 CVIGIPLTLALLSAIVARMREPSHKLRGLLNQRLGH---LFTVNHIQLIHVGVVFASL------L 199

Human   182 LFVLT-PTFVFCYME-DWSKLEAIYFVIVTLTTVGFGDYVAGADPRQD-SPAYQPLVWFWILLGL 243
            |||.. |.:||..:| |||.|:|.|:..|:|||:|.||:..|.||.|. ...|:.....:::.||
 Worm   200 LFVFAIPAWVFSSIETDWSYLDAFYYCFVSLTTIGLGDFEPGDDPNQSFRGLYKIGATVYLMGGL 264

Human   244 AYFASVLTTI 253
            ......|.|:
 Worm   265 CCMMLFLATL 274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNK4NP_201567.1 Ion_trans_2 <88..142 CDD:462301 27/60 (45%)
Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 103..108 3/4 (75%)
Ion_trans_2 180..258 CDD:462301 30/77 (39%)
Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 212..217 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 285..393
twk-46NP_741678.1 Ion_trans_2 <108..164 CDD:462301 27/55 (49%)
Ion_trans_2 198..274 CDD:462301 30/81 (37%)
Blue background indicates that the domain is not in the aligned region.

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