Protein Alignment KCNK4 and Kcnk4

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: XP_006230696.1
• Gene: Kcnk4 / 116489
• RGDID: 621449
• Length: 423
• Species: Rattus norvegicus
• Alignment Length: 398
• Identity: 328/398 - (82%)
• Similarity: 354/398 - (88%)
• Gaps: 6/398 - (1%)

Human     1 MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEV 65
            ||||||||||||||||||||||||:|||||||||.|::|.:.|::||:.|||||.:.|...||.|
  Rat    27 MRSTTLLALLALVLLYLVSGALVFQALEQPHEQQVQKDLEDGRDQFLKDHPCVSQKNLEGFIKLV 91

Human    66 ADALGGGADPETNSTSNSSH-SAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIP 129
            |:||||||:|||:.|::|:| |||:|||||||||||||||||||:||.|||||||||||||||||
  Rat    92 AEALGGGANPETSWTNSSNHSSAWNLGSAFFFSGTIITTIGYGNIALHTDAGRLFCIFYALVGIP 156

Human   130 LFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYM 194
            |||:||||||||||||||.|||||||:||||||||.|||:|||:||||||||||||||||||.||
  Rat   157 LFGMLLAGVGDRLGSSLRRGIGHIEAVFLKWHVPPGLVRMLSAVLFLLIGCLLFVLTPTFVFSYM 221

Human   195 EDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRV 259
            |.|||||||||||||||||||||||.|....|:|||||||||||||.|||||||||||||||||.
  Rat   222 ESWSKLEAIYFVIVTLTTVGFGDYVPGDGTGQNSPAYQPLVWFWILFGLAYFASVLTTIGNWLRA 286

Human   260 VSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPL----LPPPPCPAQPLGRPRSP 320
            ||||||||||||||||||||||||||||||.||:||||||||||    ||.||..|:|..||.||
  Rat   287 VSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVAEPAHRPGSP 351

Human   321 SPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGR 385
            :|.||.:.| |||||||||||||||||||||||||||||.|||||||||||||.:||.|||||||
  Rat   352 APAEKVETP-PPTASALDYPSENLAFIDESSDTQSERGCALPRAPRGRRRPNPTKKPSRPRGPGR 415

Human   386 PRDKGVPV 393
            .|||.|||
  Rat   416 LRDKAVPV 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	49/53 (92%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:462301	68/77 (88%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393		86/111 (77%)
Kcnk4	XP_006230696.1	Ion_trans_2	<111..169	CDD:462301	52/57 (91%)
		Ion_trans_2	207..285	CDD:462301	68/77 (88%)