Protein Alignment KCNK4 and kcnk4

DIOPT Version :10

• Sequence 1: NP_201567.1
• Gene: KCNK4 / 50801
• HGNCID: 6279
• Length: 393
• Species: Homo sapiens
• Sequence 2: XP_002940275.1
• Gene: kcnk4 / 100488063
• XenbaseID: XB-GENE-994204
• Length: 430
• Species: Xenopus tropicalis
• Alignment Length: 446
• Identity: 225/446 - (50%)
• Similarity: 285/446 - (63%)
• Gaps: 75/446 - (16%)

Human     1 MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEV 65
            |:..|:|||..:||.|||:||:||:.||||.|...|.:|.|.|..||..|.|:.:..|...|::|
 Frog     1 MKKKTVLALFGVVLGYLVTGAVVFQMLEQPFEALKQSQLNEHRRAFLDEHICLQEDRLDEFIEQV 65

Human    66 ADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPL 130
            .:|:|.|.||..|:|:.::.  ||:||.|||:|||||||||||.|.:||.|::||||||||||||
 Frog    66 KEAIGSGVDPSANATNVTTR--WDIGSCFFFAGTIITTIGYGNNAPKTDGGQIFCIFYALVGIPL 128

Human   131 FGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYME 195
            ||||||||||.||||||.|||.:|.:||||||...:|||:||:||:|||||||||.|.|:|..:|
 Frog   129 FGILLAGVGDHLGSSLRKGIGKVEMLFLKWHVSATIVRVISALLFILIGCLLFVLIPMFIFQKIE 193

Human   196 DWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVV 260
            :|:.||:||||::||||.||||||||.....:...|:|:||||||||||||||:||.|||||||:
 Frog   194 NWTLLESIYFVVITLTTTGFGDYVAGDGAGHEHTWYKPVVWFWILLGLAYFASILTMIGNWLRVL 258

Human   261 SRRTRAEMGGLTAQAASWTGTVTARV----------------TQRAGPAAP-------------- 295
            :|:||||||||||.||:||.::||.:                ||:.|..||
 Frog   259 TRKTRAEMGGLTAHAANWTASMTADMKLPHRGLSLNFQERLKTQKGGMRAPGQEQVDVEGEDEEQ 323

Human   296 ----PPEKEQPLLPPPPCPAQPLGRPRSPSPP--EKAQPPSPPTAS------ALDYPSENLAFID 348
                ..|:|:....||        ...|||||  ::..|.|||..:      ||:: ..|:||||
 Frog   324 EEEEEEEREEEDKDPP--------HILSPSPPIVKQTSPVSPPMKTEDMEIKALEW-GANMAFID 379

Human   349 ESSDTQSERG--------CPLPRAPRGRRRPNPPRKPVR------PRGPGRPRDKG 390
            ||||:|||:|        ....|.|||||:    |:.|:      ||.    ||||
 Frog   380 ESSDSQSEKGEGEKRVERVGRARTPRGRRK----RRGVKGDSHQFPRN----RDKG 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK4	NP_201567.1	Ion_trans_2	<88..142	CDD:462301	44/53 (83%)
		Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:462301	51/77 (66%)
		Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..393		47/162 (29%)
kcnk4	XP_002940275.1	Ion_trans_2	<85..138	CDD:462301	42/54 (78%)
		Ion_trans_2	178..256	CDD:462301	51/77 (66%)