DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PAX6 and repo

DIOPT Version :9

Sequence 1:NP_001355839.1 Gene:PAX6 / 5080 HGNCID:8620 Length:503 Species:Homo sapiens
Sequence 2:NP_477026.1 Gene:repo / 47285 FlyBaseID:FBgn0011701 Length:612 Species:Drosophila melanogaster


Alignment Length:303 Identity:88/303 - (29%)
Similarity:126/303 - (41%) Gaps:80/303 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   219 GADGMYDKLR--MLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGE--------------- 266
            |:||:.....  |:||  ||.|.:.          :...:.|.|.|.||.               
  Fly   202 GSDGLLQDSSPVMING--GSAGGKL----------KKPDEMCSQLEAGGAGVTPPSSSSTVVNGT 254

Human   267 -----NTNSISSNG-------------------EDSDEAQMRLQ---LKRKLQRNRTSFTQEQIE 304
                 |.||.||.|                   :|...::.:..   :|:|  :.||:||..|:|
  Fly   255 TNGTGNANSSSSAGVGIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKKK--KTRTTFTAYQLE 317

Human   305 ALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPIS 369
            .||:.|||..||||||||.||.|::|.|:|:||||.|||||||:.|..|......::||....::
  Fly   318 ELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTGYIKTSTPPTATLN 382

Human   370 SSFSTSVYQPIPQPT--TPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQT 432
            .......:...||.|  ||..|..|.:.. :|...||..:|.|.|..|           |..:.:
  Fly   383 PGTLAPPFTSYPQTTTVTPPGSMDSWTSY-QTPYELTPQFSLLSPAAS-----------PYGTYS 435

Human   433 SSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMG-TSGTTS 474
            ..|...:..|.....|.|:..:|..|:       || |:|:.:
  Fly   436 GQYGAYVHESQLFPMRHYEYGSPTRME-------MGATTGSVA 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAX6NP_001355839.1 PAX 85..209 CDD:128645
Homeobox 295..348 CDD:395001 35/52 (67%)
repoNP_477026.1 Homeobox 313..360 CDD:278475 30/46 (65%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6207
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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