DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAX6 and toy

DIOPT Version :9

Sequence 1:	NP_001355839.1	Gene:	PAX6 / 5080	HGNCID:	8620	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	273/531 - (51%)
Similarity:	317/531 - (59%)	Gaps:	124/531 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    83 TGGHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSI 147
            |.||||:||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly    27 TAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSI 91

Human   148 RPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLA 212
            :|||||||||||||..||.|||.||||||||||||||||||||.||.:|||||||||||||||||
  Fly    92 KPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLA 156

Human   213 SEKQQMGA---DGMYDKLRMLNGQTGSWGTRPGWYPG-------------------TSVPGQPTQ 255
            |:|:|...   :.:|:||||.|||||.|    .|||.                   .::.||..:
  Fly   157 SQKEQQAQQQNESVYEKLRMFNGQTGGW----AWYPSNTTTAHLTLPPAASVVTSPANLSGQADR 217

Human   256 DGCQQQE----GGGENTNSISS--------NGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEK 308
            |..|::|    ....:|||..|        |....:::||||:||||||||||||:.|||::|||
  Fly   218 DDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEK 282

Human   309 EFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQA-----------SNT 362
            |||||||||||||||||.||.||||||||||||||||||||||:|.|||.|           :|.
  Fly   283 EFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANN 347

Human   363 PSHIPISSSFSTSVYQPIPQPTTP--------VSSFTSGSML---------------GRTDTALT 404
            ||....|||.:||      ..:||        |:..||.:::               |..:|..|
  Fly   348 PSGTTASSSVATS------NNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHT 406

Human   405 NT---------------------YSALPPMPSFTMANNL-----PMQPPVPSQTSSYSCMLPT-- 441
            ::                     ||:: |.|..|||.|.     .|.|....|..:|..|...
  Fly   407 SSESPPLQPAAPRLPLNSGFNTMYSSI-PQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPL 470

Human   442 ---SPSVNGRSYDT--------YTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPG---SE 492
               ||.|:....:|        ..||....:.||.||.:|   :||:||.|||||||:..   |:
  Fly   471 SLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSS---NTGVISAGVSVPVQISTQNVSD 532

Human   493 PDMSQYWPRLQ 503
            ...|.||||||
  Fly   533 LTGSNYWPRLQ 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	113/123 (92%)
PAX6	NP_001355839.1	Homeobox	295..348	CDD:395001	46/52 (88%)
toy	NP_001368990.1	PAX	29..153	CDD:128645	113/123 (92%)
		COG5576	<253..368	CDD:227863	78/120 (65%)
		Homeobox	269..322	CDD:395001	46/52 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6437
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1212
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1728
Isobase	1	0.950	-	0	Normalized mean entropy	S2514
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152885at2759
OrthoFinder	1	1.000	-	-		FOG0002521
OrthoInspector	1	1.000	-	-		oto90915
orthoMCL	1	0.900	-	-		OOG6_105713
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	1	1.000	-	-		X2218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810