DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAX6 and sv

DIOPT Version :9

Sequence 1:	NP_001355839.1	Gene:	PAX6 / 5080	HGNCID:	8620	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	195/710 - (27%)
Similarity:	275/710 - (38%)	Gaps:	265/710 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    30 SQSQHAEQ---GGR---SSAAEIKRA--------------VAGANRLP-ALSLTCGGRTCLWLK- 72
            :|:||..|   |..   ||..|.|..              ::.||..| |.:.....:...|:.
  Fly    89 NQNQHGHQHLSGSNMYTSSQMEDKSKANKYDEYSSRTLSNISDANTTPSANNFITQSQGIEWITA 153

Human    73 ----PSPGSDSHVCTG-----GHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQ 128
                .:...|||...|     ||.|||||||||||||||||..||:||||||:|.|||||||.|:
  Fly   154 MNDIQNGAEDSHSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLR 218

Human   129 VSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVC 193
            ||:|||||||.|||||||.:...||||||:||||.||..||.||||.|::||||||||||:|.:|
  Fly   219 VSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAIC 283

Human   194 TNDNIPSVSSINRVLRNLASEK-------------QQMGADGMYDKLRMLNGQTGSWGTRPGWYP 245
            :.||:||||||||::||.|:||             |.:|  |.:.....::..||:.|.
  Fly   284 SQDNVPSVSSINRIVRNKAAEKAKHVHHHQQHHVSQSLG--GGHIATESVDSSTGTIGE------ 340

Human   246 GTSVPGQPTQDGCQQQEGGGENTN---------SISSNGEDSDEAQM---------RLQLKRKLQ 292
                |..||.:    ......|||         ||.::|.||.:..:         ...:....:
  Fly   341 ----PQPPTSN----SSANSVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAE 397

Human   293 RNRTSFT---------------------------------QEQIEALEKEFERTHYP--DVFARE 322
            :..|.::                                 :::|||.::..:...:.  |...|:
  Fly   398 QRTTGYSINGILGIQHGHHSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQ 462

Human   323 RLAAKIDLPEARIQVWFSNRRAKW--RREEKLRNQ--------------RRQASNTPSHIPISSS 371
            |::. ....:....:|    ..||  :.:.||..:              ..:|||..|..|||.|
  Fly   463 RMST-YSGDQLYTNIW----SGKWCIKDDHKLLAELGNLTASTGNCPATYYEASNGFSTTPISGS 522

Human   372 FST---------------------SVYQPI--PQ-------PTTPVS------------------ 388
            .:|                     |:|.|.  |.       |..|:|
  Fly   523 GATASGNDTSMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPP 587

Human   389 ---------SFTSGSMLGRTDTALTNTYSALPP--------------MPSFTMANNLPMQPPVPS 430
                     ::||.:.|....:.:...:..:|.              :|..|..|:..::.|:
  Fly   588 FYTALAFDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNSTRVKEPL-- 650

Human   431 QTSSYSCMLPTS----PSVNGRSYDTYTPPHM------------------QTHMNS----QPMGT 469
             |:|..|....:    .|.:.:|.|....||:                  .||.:|    ||.|.
  Fly   651 -TNSDGCSEDNNKEPEKSNSSQSSDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSGG 714

Human   470 SG-----------------TTSTGLISPGVSVP----------VQVPGSE----PDMSQY 498
            |.                 :.:.||.|....:|          ..||||:    |..:||
  Fly   715 SSLLNINPSENRSDVELNLSNNVGLYSTPTVLPSFNHYSAGCSSVVPGSDYAYNPAYTQY 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	93/123 (76%)
PAX6	NP_001355839.1	Homeobox	295..348	CDD:395001	10/89 (11%)
sv	NP_524633.3	PAX	175..299	CDD:128645	93/123 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910