Protein Alignment PAX6 and ey

DIOPT Version :9

• Sequence 1: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 272/674 - (40%)
• Similarity: 315/674 - (46%)
• Gaps: 233/674 - (34%)

Human    23 PWNPAA-----PSQSQHAEQGGRSSAAEIKRAVAGANRLPALSLTCGGRTCLWL--KPSP----- 75
            ||:...     ||....|.          |..|.....||.|. |.||.....:  ||||
  Fly    17 PWSAGTLIERLPSLEDMAH----------KDNVIAMRNLPCLG-TAGGSGLGGIAGKPSPTMEAV 70

Human    76 ---------GSDSHVCT--------GGHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDI 123
                     .:.|:..|        ..||||||||||||.|||||||||||||||||||||||||
  Fly    71 EASTASHPHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDI 135

Human   124 SRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLL 188
            ||||||||||||||||||||||||||||||||||||||.||||||:|||||||||||||||||||
  Fly   136 SRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLL 200

Human   189 SEGVCTNDNIPSVSSINRVLRNLASEKQQM----------------------------------- 218
            .|.|||||||||||||||||||||::|:|.
  Fly   201 QENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSR 265

Human   219 ----------------------GA---------DGMYDKLRMLNGQTG----------------- 235
                                  ||         :.:|:|||:||.|..
  Fly   266 GTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQ 330

Human   236 ----------------------------SWGTR---PGWYPGTSVPGQPTQ-------------- 255
                                        ||..|   ..||| ||:...|..
  Fly   331 SPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYP-TSLSEIPISSAPNIASVTAYASG 394

Human   256 --------------------------------------DGCQQQE---GGGENTNSISSNGEDSD 279
                                                  ||.|..|   |.|||:|..:||..:::
  Fly   395 PSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTE 459

Human   280 EAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRA 344
            :.|.||.|||||||||||||.:||::||||||||||||||||||||.||.|||||||||||||||
  Fly   460 DDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRA 524

Human   345 KWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSA 409
            |||||||||||||..::|.:....||:.:|:.....|...:..||..|||..|.:.:.:....|
  Fly   525 KWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSS- 588

Human   410 LPPMPSFTMAN-NLP--------MQPPVPSQTSSYSCMLPTSPSVNGRSYD------TYTPPHMQ 459
                ||....| |.|        .:.|.|......||   ||.:.|||..:      :..|..:.
  Fly   589 ----PSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSC---TSDNDNGRQSEDCRRVCSPCPLGVG 646

Human   460 THMNSQPMGTSGTTSTGLISPGVS 483
            .|.|:..:.::|......:.|.:|
  Fly   647 GHQNTHHIQSNGHAQGHALVPAIS 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	117/123 (95%)
		Homeobox	295..348	CDD:395001	46/52 (88%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	117/122 (96%)
		Homeobox	475..527	CDD:278475	45/51 (88%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I2238
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152885at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.910