Protein Alignment PAX6 and Zasp66

DIOPT Version :9

• Sequence 1: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_729395.2
• Gene: Zasp66 / 38988
• FlyBaseID: FBgn0035917
• Length: 430
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 89/459 - (19%)
• Similarity: 152/459 - (33%)
• Gaps: 148/459 - (32%)

Human    73 PSP---GSDSHVCTGGHSGVNQLGGVFV----NGRPLPDSTRQKIVE-----LAHSGARPC---- 121
            |||   .|.|.:....|....|..||.|    :|..|......||.|     |:|:.|:..
  Fly    43 PSPCRRRSSSGLKKRVHFADEQNVGVQVGSPAHGELLRGDIISKIGEYDARDLSHADAQQLFRGA 107

Human   122 --DISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIR 184
              :|..::...|. ::...|...|.|.       ||:.....|.|...:..::...|.:......
  Fly   108 GNEIRLVVHRDNK-IAYTQGATQEAGP-------GSRSNSTLPPVTPDLMPHRGPSPFLPGPSHF 164

Human   185 DRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSV 249
            :|.|...|   |.:|.            :...|:.:.|.|:                  .|.|..
  Fly   165 ERALQLPV---DTLPQ------------TVFPQLNSSGGYE------------------VPSTVF 196

Human   250 PGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTS-----FTQEQIEALEKE 309
            ..:||:|                 :.:|.||.|..:    ..|..||:     ..:.:.:|...|
  Fly   197 SPKPTRD-----------------HQQDVDEEQAAI----VNQPYRTTPLVLPGAKVKKDAPTTE 240

Human   310 FERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFST 374
            ....|||:             |..|......       ..:.:..||  .::|..|..:.|...|
  Fly   241 SYLRHYPN-------------PAVRAHPGHD-------YHDSIMKQR--VADTMLHKVVGSEADT 283

Human   375 S-VYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANN----LPMQPPVPSQTSS 434
            . |:.  .|..:|:..:::.::    :..:.:|      :|..|..:|    .|:..|:|::.:.
  Fly   284 GRVFH--KQFNSPIGLYSNNNI----EDTIRST------VPFATSESNRLKDSPLHRPLPTKLNG 336

Human   435 YSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISP-GVSVPVQ---------VP 489
            |            :....|.|.:.:|:...|..|  |.::.|..|| .|::|||         ||
  Fly   337 Y------------KKTVQYDPRNSETYRAIQEEG--GYSNYGQSSPQEVTIPVQTKVYQPNRLVP 387

Human   490 GSEP 493
            |.:|
  Fly   388 GKKP 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	28/138 (20%)
		Homeobox	295..348	CDD:395001	9/57 (16%)
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	11/46 (24%)
		DUF4749	285..359	CDD:292558	16/99 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030