DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAX6 and Zasp52

DIOPT Version :9

Sequence 1:	NP_001355839.1	Gene:	PAX6 / 5080	HGNCID:	8620	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	121/627 - (19%)
Similarity:	199/627 - (31%)	Gaps:	188/627 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    12 TSEISEPH-----IRAPWNPAAPSQSQHAEQGGRSSAAEIKRAVAGANRL------------PAL 59
            ||:.|..|     :.||....|||:.:..|:..:.|...|....:|...:            .||
  Fly  1443 TSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELVRPDQAL 1507

Human    60 SLTCGGRTCLWLKPSP------GSDSHV---CTGGHS-GVNQLGGVFVNGRPLPDSTRQKIVELA 114
            :.|......|..||:|      ..:..|   |:..|: ..|:|     |..|.||.||...
  Fly  1508 TPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSATHARNYNEL-----NASPFPDRTRSPA---- 1563

Human   115 HSGARPCDI--------------SRILQVSNG----CVSKILGRYYETGSIRPRAIGGS------ 155
             .|..|..:              |.||.||.|    ..|...|:.|: |.:...:...|
  Fly  1564 -PGPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQSYQ-GQLLAHSEQSSQSASQS 1626

Human   156 ---KPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQ 217
               :|...|.:.|..:...:||..|....:.:.:..|:   |...:.:.....|  |.:..|.::
  Fly  1627 YNQQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQ---TRSQVGNTQIERR--RKVTEEFER 1686

Human   218 MGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQ 282
            .      ...:.:..:|||...........|:....||  .|.|.....:|...||.|:....|.
  Fly  1687 T------QSAKTIEIRTGSQSVSQSKAQSQSISQAQTQ--AQSQSQNQSDTERRSSYGKTGFVAS 1743

Human   283 MRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 347
                     |..|.|..:|:|.:|..:.:.     :.||.....:...|..|...:.|....|..
  Fly  1744 ---------QAKRLSCMEEEISSLTSQSQA-----ISARASALGEGCFPNLRSPTFDSKFPLKPA 1794

Human   348 REEKL------------------------RNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVS 388
            ..|.:                        :.|::|.|....:...:||...|.:....:.||  |
  Fly  1795 PAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATT--S 1857

Human   389 SFTSGSMLGRTDTALTNTYSALPPMPSFTMAN------------------NLPMQPPVPSQTSSY 435
            |.:|.|.......::..:..:|....:.|...                  ||..:|.:.|.|:..
  Fly  1858 SLSSSSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPG 1922

Human   436 SCMLP-----------TSP--------SVNGRSYDTYTPP------------HMQTHMNSQP--- 466
            |...|           |:|        ||...:.:...||            ::.:::::.|
  Fly  1923 SASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAG 1987

Human   467 ---MGTSGTTST-----GLIS----PGVSVP------VQVPG 490
               .|..|.||.     |:::    |||.:|      ||:.|
  Fly  1988 GKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRG 2029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	31/151 (21%)
PAX6	NP_001355839.1	Homeobox	295..348	CDD:395001	11/52 (21%)
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	3/10 (30%)
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030