Protein Alignment PAX6 and Gsc

DIOPT Version :9

• Sequence 1: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 381
• Identity: 106/381 - (27%)
• Similarity: 149/381 - (39%)
• Gaps: 88/381 - (23%)

Human    13 SEISEPHIRAPWNPAAPSQSQHAEQGGRSSAAEIKRAVAGANRLPAL-----SLTCGGRTCLWLK 72
            |.:.:.|.:...:.:....|....|.|.:...|.:|..|.|..|..:     |...||.|
  Fly   120 SVLQQQHAQHQQSQSQTPSSDDGSQSGVTILEEERRGGAAAASLFTIDSILGSRQQGGGT----- 179

Human    73 PSPGSDSHVCTGGHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKI 137
             :|...||:.:.|    || .|:..||..|         .|..|||.    |.....||...|.
  Fly   180 -APSQGSHISSNG----NQ-NGLTSNGISL---------GLKRSGAE----SPASPNSNSSSSA- 224

Human   138 LGRYYETGSIRPRAIGG--SKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPS 200
                 ....|||:.:..  ..|.:....:.:..|......||.|.           |...:..|:
  Fly   225 -----AASPIRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFL-----------VAYPNFYPN 273

Human   201 VSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYP-----GTSVPGQPTQDGCQQ 260
            ......| .::|:.:.|....|   ....|:|. |.....|..:|     |....||
  Fly   274 YMHAAAV-AHVAAAQMQAHVSG---AAAGLSGH-GHHPHHPHGHPHHPHLGAHHHGQ-------- 325

Human   261 QEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLA 325
                    :.:|..|.....       ||| :|:||.||:||:|.||..|::||||||..||:||
  Fly   326 --------HHLSHLGHGPPP-------KRK-RRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLA 374

Human   326 AKIDLPEARIQVWFSNRRAKWRR-----EEKLRN-QRRQASNTPSHIPISSSFSTS 375
            .|:||.|.|::|||.|||||||:     :|:||. |..|..:|.:....|||.:||
  Fly   375 LKVDLKEERVEVWFKNRRAKWRKQKREEQERLRKLQEEQCGSTTNGTTNSSSGTTS 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	26/125 (21%)
		Homeobox	295..348	CDD:395001	34/52 (65%)
Gsc	NP_001137762.2	Homeobox	343..396	CDD:278475	33/52 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940