Protein Alignment PAX4 and ey

DIOPT Version :9

• Sequence 1: NP_001353039.1
• Gene: PAX4 / 5078
• HGNCID: 8618
• Length: 351
• Species: Homo sapiens
• Sequence 2: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 167/567 - (29%)
• Similarity: 217/567 - (38%)
• Gaps: 240/567 - (42%)

Human     7 SSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKG 71
            |.:|||||:||.|||||..|||:||.||.||.|||||||||:||||||||||||||.||.:.|:.
  Fly    99 SGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRA 163

Human    72 IGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLR--ALQED 134
            |||||||:||..||::|:|.|.|||::|||||:.:|..|.:||.|..|||||||||||  |.|::
  Fly   164 IGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKE 228

Human   135 Q-----GLPCT------------------------------------------------------ 140
            |     |...|
  Fly   229 QQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSG 293

Human   141 ----------RLR--------SPAVLAPAVLTP-------HSGSETPRGTHP------------- 167
                      :||        .|..|.||...|       |.|:   |.:||
  Fly   294 EGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGT---RSSHPQLVHGNHQALQQH 355

Human   168 ----------------------------------------------------------------- 167
                                                                             
  Fly   356 QQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCP 420

Human   168 --------------------GTG----------------------------HRNRTIFSPSQAEA 184
                                |:|                            .||||.|:..|.::
  Fly   421 VATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDS 485

Human   185 LEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRV 249
            |||||:|..|||..||.:||....|||..::||||||||||||:|||:.:.:.|.::........
  Fly   486 LEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSS 550

Human   250 APGIISAQQSPGSVPT-AALPALEPLGPSCYQLCWATAPERC--------------LSDTP-PKA 298
            .....|...||.|:.. ::|.:....|||...:...::|...              .|::| |..
  Fly   551 TSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIP 615

Human   299 CLKP-CWGHLPPQPNSLDSGLLCLPCP-------SSHCHLASLSGSQ 337
            .::| |.........|.|...:|.|||       ::| |:.|...:|
  Fly   616 HIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTH-HIQSNGHAQ 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX4	NP_001353039.1	PAX	5..129	CDD:128645	84/121 (69%)
		Homeobox	174..226	CDD:306543	29/51 (57%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	84/121 (69%)
		Homeobox	475..527	CDD:278475	29/51 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152885at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020