Protein Alignment PAX3 and repo

DIOPT Version :10

• Sequence 1: NP_852124.1
• Gene: PAX3 / 5077
• HGNCID: 8617
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_477026.1
• Gene: repo / 47285
• FlyBaseID: FBgn0011701
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 372
• Identity: 103/372 - (27%)
• Similarity: 143/372 - (38%)
• Gaps: 118/372 - (31%)

Human    14 PGPGQNYPRSGFPL-EVSTPLGQGRVNQLGGVF----INGR------PL----PNHIRHKIVEMA 63
            |.|..|    |..| :.|:...|.:..||.|:.    :||:      |.    |..::|......
  Fly   133 PPPSHN----GILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSP 193

Human    64 HHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGM 128
            ||         ...:.||  |..|.:......|..|:.||                  |.:.|
  Fly   194 HH---------LDHLDHG--SDGLLQDSSPVMINGGSAGG------------------KLKKP-- 227

Human   129 FSWEIRDKLLKDAVCDR------NTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHS 187
                       |.:|.:      ...|..||.:.:..:..|.|.           ..|...|...
  Fly   228 -----------DEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGN-----------ANSSSSAGVG 270

Human   188 IDGILSER--ASAPQS-DEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTR 249
            |.|.....  .:||.: .:||....:.| |...|::::||||||.|||||||||||..|||::.|
  Fly   271 IQGAAGTAGGVAAPAAKKDGSSSKKKGD-PNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAR 334

Human   250 EELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQP 314
            ||||.:..|:|:||||||.||||:|||..                ||           .:|.|..
  Fly   335 EELAIKLNLSESRVQVWFQNRRAKWRKHE----------------PP-----------RKTGYIK 372

Human   315 TSIPQAVSDPSSTVHRPQPLPPSTVHQSTI----PSNPDSSSAYCLP 357
            ||.|     |::|::.....||.|.:..|.    |.:.||.::|..|
  Fly   373 TSTP-----PTATLNPGTLAPPFTSYPQTTTVTPPGSMDSWTSYQTP 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		3/6 (50%)
		PAX	34..159	CDD:128645	26/144 (18%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	37..93		14/69 (20%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	113..161		7/53 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..228		16/65 (25%)
		Homeodomain	220..276	CDD:459649	38/55 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		13/45 (29%)
		Pax7	347..391	CDD:403540	4/11 (36%)
repo	NP_477026.1	Homeodomain	313..361	CDD:459649	33/47 (70%)