DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAX3 and Poxm

DIOPT Version :9

Sequence 1:	NP_852124.1	Gene:	PAX3 / 5077	HGNCID:	8617	Length:	505	Species:	Homo sapiens
Sequence 2:	NP_001036687.1	Gene:	Poxm / 40990	FlyBaseID:	FBgn0003129	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	142/417 - (34%)
Similarity:	179/417 - (42%)	Gaps:	107/417 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    36 GRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA 100
            |.||||||||:|||||||..|.:|||:|..|||||.||||||||||||||||.||.|||||.|||
  Fly    11 GEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGA 75

Human   101 IGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGK- 164
            ||||||: ||||.|...|.|.|:.:||:|:|||||:||.:.:||:..||||||||||||:|.|.
  Fly    76 IGGSKPR-VTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLGSL 139

Human   165 GEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAE 229
            |.:                  |:...::...:|:    .|..:.|...      |....:.....
  Fly   140 GHQ------------------HTPGTVMGSGSSS----GGGSVSSNGG------QNNGTSASNNI 176

Human   230 QLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGF 294
            .|..|.......|:|..:...:.|..|                     |.|:.:.|..|
  Fly   177 NLSNLGNPGGGPHHPHHHHHHQSAAAA---------------------ASAHHVHAHAH------ 214

Human   295 PPTAMPTLPTYQLSETSYQPTSIPQAVS--DPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLP 357
                    ....|..:.|||.|...|.|  .|..:   |.| |.....|.::|......|.....
  Fly   215 --------AHAHLYNSIYQPYSAAAAYSMKTPCGS---PSP-PQGAGGQGSVPHPHQLRSVAAAA 267

Human   358 STRHGFSSYT-----------------------------DSFVPPSGPSNPMNPTIGN-GLSPQV 392
            :..|..||::                             .|.|.|. |..| :|..|. |..|
  Fly   268 AAAHWPSSHSVSDILAHHQAVALRASCQVGVGVGGMGGMGSTVSPL-PMTP-SPVAGTAGGQP-- 328

Human   393 MGLLTNHGGVPHQPQTDYALSPLTGGL 419
              ||...||...|...:|.:....||:
  Fly   329 --LLDCEGGAGQQSPYNYYMYFQNGGM 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PAX	34..159	CDD:128645	88/122 (72%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	37..93		43/55 (78%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	113..161		28/47 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..228		6/62 (10%)
		Homeobox	222..276	CDD:395001	6/53 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		12/43 (28%)
		Pax7	347..391	CDD:403540	12/73 (16%)
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	88/122 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910