Protein Alignment PAX3 and eyg

DIOPT Version :10

• Sequence 1: NP_852124.1
• Gene: PAX3 / 5077
• HGNCID: 8617
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 168/562 - (29%)
• Similarity: 233/562 - (41%)
• Gaps: 177/562 - (31%)

Human     5 AGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGV-FINGRPLPNHI-----RHKIVEMA 63
            |||....:..|.|..   |..|..|..|.|.|.....||: ...|.|..:.:     :|:::|.:
  Fly    65 AGAGSGAVAGGGGAT---STSPTSVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFS 126

Human    64 HH-GIRPCVISRQLRVSHGCVSKILCRYQETGSIR-PGAIGGSKPKQVTTPDVEKKIEEYKRENP 126
            .. |:|...|::.:....|.|||:|      ||:| ||.||||||| |.||.|..|||:||||||
  Fly   127 RFGGLRGYDIAQHMLTQQGAVSKLL------GSLRPPGLIGGSKPK-VATPTVVSKIEQYKRENP 184

Human   127 GMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKH----- 186
            .:|:||||::|:.:.||...|.||||||:||||::  ..|....:..|..|........|
  Fly   185 TIFAWEIRERLISEGVCTNATAPSVSSINRILRNR--AAERVATEFARTAAYGLYPPPPHPYGSF 247

Human   187 --------------------------------------------SIDGILS-------------- 193
                                                        |..|.||
  Fly   248 TWHPAGNVPGGQGVPPPPPPSALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPT 312

Human   194 ERASAPQS---------DEGSDIDS----EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPD 245
            .||.:|.|         ||...|||    :.|.|   |.||:||||:.|||||||:.|:::|||.
  Fly   313 NRAISPGSGSHDTLESADENRHIDSDYLDDDDEP---KFRRNRTTFSPEQLEELEKEFDKSHYPC 374

Human   246 IYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSET 310
            :.|||.|:.|..|:|||||||||||||:||:....|.|..          ..:.|..|.:. .::
  Fly   375 VSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKR----------QRSSPANPLHS-QQS 428

Human   311 SYQPTSIPQAVSDPSSTVHRP-QPLPPSTVHQSTIPSNPDSSSAYCLPST----RHGFSSYTDSF 370
            :..|.|.|...:..|::...| .|:||.   |..:|...|.|.....||.    .||
  Fly   429 NDAPASSPTPSNHSSASTSAPVAPVPPP---QQPLPLCGDHSPQGPPPSVLLHPLHG-------- 482

Human   371 VPPSG--PSNPMN-PTIGNGLSPQVMGLLTNHGGVPHQP-----------------QTDYALSPL 415
             ||.|  ..:|:: ||     .|..:.||:::    ||.                 |....|||
  Fly   483 -PPGGHHHHHPLHLPT-----HPAALQLLSHY----HQQQQQQQQQQHQQQQQQHHQQQQQLSP- 536

Human   416 TGGLEPTTTVSASCSQRLDHM---------KSLDSLPTSQSY 448
                       :.|:...:|:         :||.|.|::.::
  Fly   537 -----------SGCNPAANHLSMGGERSAFRSLVSSPSAAAF 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		5/15 (33%)
		PAX	34..159	CDD:128645	58/132 (44%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	37..93		14/62 (23%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	113..161		29/47 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..228		26/138 (19%)
		Homeodomain	220..276	CDD:459649	37/55 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		11/42 (26%)
		Pax7	347..391	CDD:403540	12/50 (24%)
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197	52/103 (50%)
		Homeodomain	349..405	CDD:459649	37/55 (67%)