Protein Alignment PAX3 and Vsx1

DIOPT Version :10

• Sequence 1: NP_852124.1
• Gene: PAX3 / 5077
• HGNCID: 8617
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_572232.2
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 216
• Identity: 66/216 - (30%)
• Similarity: 101/216 - (46%)
• Gaps: 31/216 - (14%)

Human   186 HSIDGILSERASA---PQS---DEGSDI-----DSEPDLPLKRKQRRSRTTFTAEQLEELERAFE 239
            |..:..|.....|   |.|   ..|.|:     .:.|....|.|:|..||.||:.||||||:||:
  Fly   351 HHAEAFLGAAGGAGGNPNSLLAAHGGDVLVGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFK 415

Human   240 RTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQA---GANQLMAFNHLIPGGFPPTAMPT 301
            ..||||:..||.|:.:..|.|.|:|||:.||||:|||..   |.:..|| .:.:.|.....::|
  Fly   416 EAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMA-EYGLYGAMVRHSLP- 478

Human   302 LPTYQLSETSYQPTSIPQAVSDPSSTVHRPQ----PLPPSTVHQSTIPSNPDSSSAYCLPSTRHG 362
                 |.||..:.....::|:.....:|:..    .|..|.......|::.|::::|...||.:.
  Fly   479 -----LPETIIKSAKEDESVAPWLLGMHKKSLEAAELLKSDESDRETPTSDDTNTSYSAGSTHNS 538

Human   363 -FSSYTDSFV-----PPSGPS 377
             .||::.|.:     ||:..|
  Fly   539 PISSFSISRLLFDAPPPAAGS 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PAX	34..159	CDD:128645
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	37..93
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	113..161
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..228		14/52 (27%)
		Homeodomain	220..276	CDD:459649	31/55 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		8/45 (18%)
		Pax7	347..391	CDD:403540	10/37 (27%)
Vsx1	NP_572232.2	Homeodomain	395..452	CDD:459649	31/56 (55%)