Protein Alignment PAX3 and Vsx2

DIOPT Version :10

• Sequence 1: NP_852124.1
• Gene: PAX3 / 5077
• HGNCID: 8617
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 247
• Identity: 75/247 - (30%)
• Similarity: 104/247 - (42%)
• Gaps: 60/247 - (24%)

Human   216 KRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQA-- 278
            |:|:|.|||.||:.|||:||.||:..||||:|.||.|:.:.:|.|.|:||||.||||:|||..
  Fly   227 KKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKV 291

Human   279 -GANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQS 342
             |.:.:|| .:.:.|.....::| ||...|..........|..:......:||     .|...||
  Fly   292 WGGSTIMA-EYGLYGAMVRHSLP-LPDTILKSAKDNDAVAPWLLGMEQKCMHR-----KSIEAQS 349

Human   343 TIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQ 407
            .:   .|.|          |.|.:.||....|..|..::.:
  Fly   350 AL---KDDS----------GVSDHEDSAGSKSAHSEDLSRS------------------------ 377

Human   408 TDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYS 459
            ..:|||..|..|...:...:||             |||.|...|..||:||:
  Fly   378 RCHALSSSTESLNVVSPAPSSC-------------PTSASTSAPPTSTSGYA 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PAX	34..159	CDD:128645
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	37..93
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	113..161
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..228		7/11 (64%)
		Homeodomain	220..276	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		7/41 (17%)
		Pax7	347..391	CDD:403540	8/43 (19%)
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	33/56 (59%)
		OAR	556..572	CDD:461067