DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp8a2 and CG33298

DIOPT Version :9

Sequence 1:	NP_056618.1	Gene:	Atp8a2 / 50769	MGIID:	1354710	Length:	1148	Species:	Mus musculus
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1306	Identity:	418/1306 - (32%)
Similarity:	634/1306 - (48%)	Gaps:	266/1306 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 SVGDQLEAPA-RIIYLN---------QSHLN-KFCDNRISTAKYSVLTFLPRFLYEQIRRAANAF 59
            :.||:.|..: |.:..|         :.|.| :|..|:|.|.||::|:|:|:.|.||..|.||.:
  Fly   217 NTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLY 281

Mouse    60 FLFIALLQQIPDVSPTGRYTTLVPLVIILTIAGIKEIIEDFKRHKADNAVNKKKTIVLRNG---M 121
            |:||.||..:|::|..|:...::|::.:|.:..:|::.||.:|..:|..:| ..|..:.:|   .
  Fly   282 FIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRIN-NTTCRVYDGETER 345

Mouse   122 WHTIMWKEVAVGDIVKVLNGQYLPADMVLFSSSEPQGMCYVETANLDGETNLKIRQGLSHTTDMQ 186
            :..:.|:|:.|||||.:.|.:.:|||::|..:|:|||:||::|.:||||||||.|:.:....:||
  Fly   346 YKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQ 410

Mouse   187 TRDVLMKLSGRIECEGPNRHLYDFTGNL-HLDGKSSVALGPDQILLRGTQLRNTQWVFGVVVYTG 250
            :..|..|...|:|.:.|...||.|.|.| |..|: .|.:..:.:|||.::|:||.::.|:|||.|
  Fly   411 SIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGE-RVPISTECLLLRESRLKNTDYIEGIVVYAG 474

Mouse   251 HDSKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSVGALFWNGS--HGGKSWYI--KK 311
            |::|.|.|::....|||.||:..|:.::....|||::.:|.::|...|..|  |.... |:  .|
  Fly   475 HETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVP-YLPPNK 538

Mouse   312 MDTNSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDMDMYYIENDTPAMARTSNLN 376
            :..|.::. :...|:|::...:||:||.||:|:.|..|...|:.::|::..|.:.....|..|:.
  Fly   539 LTANMESM-WIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNIT 602

Mouse   377 EELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFP-ELAREQSSDDFCRMTSCTNDSCDFND 440
            |||||::::|:|||||||.|.|.|::|.:.|..|.|.| ||.:..|...........||:.: :|
  Fly   603 EELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLN-SD 666

Mouse   441 PRLLKNIEDQHPTAPCIQEFLTLLAVCHTVV----PEKD-------------------------- 475
            ...|.......|.|..|||||.:||:|:||:    |.:|
  Fly   667 MAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQR 731

Mouse   476 ------------------------------GDEII------------------------------ 480
                                          .|..|
  Fly   732 QKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLS 796

Mouse   481 ----------------------------------------------------------------- 480

  Fly   797 PISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSS 861

Mouse   481 --------------YQASSPDEAALVKGAKKLGFVFTGRTPYSVIIE--AMGQEQTFGILNVLEF 529
                          |:|.||||.|||..|.........|:|..:::.  ..|..:.:.||.||.|
  Fly   862 KTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPF 926

Mouse   530 SSDRKRMSVIVR-LPSGQLRLYCKGADNVIFERL------SKDSKYMEETLCHLEYFATEGLRTL 587
            .|.||.||::|| :.|.::.||.||||:.|...|      |.:....|:|...|:.:|.||||.|
  Fly   927 DSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRIL 991

Mouse   588 CVAYADLSENEYEEWLKVYQEASIILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIA 652
            .:|...|:..:|.:|...:||..:.|::|.:||.:.:..:|.||.|||||.||||||.|||||||
  Fly   992 VMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIA 1056

Mouse   653 TLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGN----- 712
            :||.|.|.:|||||||.||||||.||.:|.:|.|.||.|...|.||...||..:.||:.|
  Fly  1057 SLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTS 1121

Mouse   713 LLG-----KENDVALIIDGHTLKYAL--SFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKK 770
            .||     ::...||::||.||.:.|  ..::...||.|:..|.:|:|||.:||||:.:|.|||:
  Fly  1122 TLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKE 1186

Mouse   771 RVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRV 835
            .:...|||||||||||.|||.|.|||||||.|||||...:|:.:.:|.|||:|||.||.|.|:|:
  Fly  1187 ELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRL 1251

Mouse   836 TKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESM 900
            ::.|||.||||.....:..|:....|||||::.::..:.|||:|||:|||..:|::::...::.:
  Fly  1252 SRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLL 1316

Mouse   901 LRFPQLYRITQNAEGFNTKVFWGHCINALVHSLILFWVPMKA-LEHDTPVTSGHATDYLFVGNIV 964
            |:.|.||:..:....:....||...::||..||::|:|.:.| .|.|             ||...
  Fly  1317 LKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESD-------------VGIWE 1368

Mouse   965 YTYVVVTVCLKAGL-----ETTAWTKFSHLAV---WGSMLIWLVF--------FGVYSTIWPTIP 1013
            :...:...||.|.|     |..:||....|::   .||..::.:.        |||.|:.|...
  Fly  1369 FGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIF- 1432

Mouse  1014 IAPDMKGQATMVLSSAYFWLGLFL-----VPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRV 1073
                      :..:||..||.:.|     |....|:..|..........|.:|:..:|     |.
  Fly  1433 ----------VCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRE-----RS 1482

Mouse  1074 MGKAML 1079
            .|:|:|
  Fly  1483 RGEALL 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp8a2	NP_056618.1	PhoLip_ATPase_N	17..79	CDD:292826	26/71 (37%)
		ATPase-Plipid	28..1066	CDD:273734	406/1258 (32%)
		E1-E2_ATPase	85..>170	CDD:278548	30/87 (34%)
		Cation_ATPase	466..564	CDD:289987	41/275 (15%)
		HAD_like	<776..805	CDD:304363	24/28 (86%)
		PhoLip_ATPase_C	808..1059	CDD:292829	76/272 (28%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	22/49 (45%)
		ATPase-Plipid	250..1473	CDD:273734	404/1251 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	31/92 (34%)
		Cation_ATPase	<880..965	CDD:289987	32/84 (38%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	76/268 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830