Protein Alignment Dlc1 and cv-c

DIOPT Version :9

• Sequence 1: NP_001181869.1
• Gene: Dlc1 / 50768
• MGIID: 1354949
• Length: 1543
• Species: Mus musculus
• Sequence 2: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 1715
• Identity: 486/1715 - (28%)
• Similarity: 729/1715 - (42%)
• Gaps: 505/1715 - (29%)

Mouse   127 ILTPQRH-------------ERDSQDSVKGAGSFMKTLSTMQSSQDSHNTWRMAGKADMSPAEGS 178
            :|.|::|             ..::..:.|...::|:|||.....        .|.......|.||
  Fly   838 VLKPEKHATIPLQSFYLDCGRNEASPATKSNVAYMRTLSAPNGG--------FASGGGGGAARGS 894

Mouse   179 G-ERKDVEAINKSLGLCK--NTSADETKDVPIGNTFQSLNTEDDVTPKTLLLDSSVLIEDV---- 236
            | .....::..|||. |.  |..||.....|             .|.|.....|::.||::
  Fly   895 GAPALPPQSQRKSLA-CPPLNGQADTITPTP-------------ATHKLTNFQSALKIEEMAAAK 945

Mouse   237 -----TPETQLLDSAVITQQCRKSDFPKDDQENNRHHVLEEDVLAAPYVDR-GLPLLKADCRSSL 295
                 |.|:||..:....:..|:......|.|.    :|....::.|  .| |:.......|:::
  Fly   946 GTAMATGESQLATTIEDLKSRRQRQLSGGDMET----MLASQPMSMP--KRVGINHAVLTSRNAI 1004

Mouse   296 LQPP--------------SCPGGMSA-----------------------------------END- 310
            ..||              |..|..||                                   :|:
  Fly  1005 TPPPASASSASQSAASVHSAKGSSSAGTTPGYLVDVTKKGSTSTIWTSEESILRSVGAVDEDNNS 1069

Mouse   311 ----------------------LEKSGFSEYQNKSTLGVS----------REDGMQCLH------ 337
                                  |:.||.....|:|.:|.:          :...:|..|
  Fly  1070 TSSSSACEEATGVLSSGKSGISLDSSGLDNDNNESGIGTATPPKDMSHYWKSHHLQHHHHHHHRK 1134

Mouse   338 LRGPVTTQETVDNQVRLRKRKETREDRDRTRLDSMVLLIMKL------------DQLDQ------ 384
            ..|.....|:|.:...|||.|..:.....:..|..||.::..            |.||:
  Fly  1135 CTGSAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLEVLSQCGSGGEANESQDDMLDEEKDKMS 1199

Mouse   385 ---------DIENALSTASSPS------STPTNLRR----------------------HVP---- 408
                     |.:.....|||.|      :||..|||                      |.|
  Fly  1200 KSQDYDEIWDCDCTDGDASSASGGGGVTATPVILRRKYTAPPPILVPRTQRSHSLDHYHSPQPLV 1264

Mouse   409 --------------DLESGS----------ESRTDSMAVNQTQVNLSSESTDPSSTP-----GSN 444
                          ..|.|.          :|.....|....|::...|...|||..     |.:
  Fly  1265 HPRKVLPIHHHALKSKERGQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSASLHSGLGDS 1329

Mouse   445 SGTK---PKAMAAP-CVGEKEM-------------------------AEIEAKEACDWLRVTGFP 480
            .|.:   .|:.:|| .:.|:||                         |||||.|||.|||..|||
  Fly  1330 GGIQELCTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFP 1394

Mouse   481 QYAQLYEDLLFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEIS--PHRKRSEDSDED 543
            ||||:|||..||||:..|.::|..|:.|.:::|.|||..||:||.|:|:.|  |...:.::..:|
  Fly  1395 QYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESDD 1459

Mouse   544 EPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSHESMLTDLSEHQEVASV 608
            |..|:|..||||...:||||:.|..:    :.|.||.                  ||.:.|
  Fly  1460 ENFALSEHWTFQPHIRRWSRIGEMGL----ELPPPGL------------------LSLNVE---- 1498

Mouse   609 RSLSSTSSSVPTHAAHSGDATTPRTNSVISVCSSGHFVGNDDSFSSLPSPKELSSFSFSMKGHHE 673
            ::.||:..|.|......|...|    .|...||....:.||.  |||..    .|.|..::....
  Fly  1499 KTESSSKESSPDRFEEDGAGIT----LVTPGCSKAGGIPNDG--SSLGE----GSDSGRLRRSGS 1553

Mouse   674 KNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPI---LQEGMDEAKLKQLNCV----- 730
            :..|.:.::||:|:||:|.:     :.|..::..::||.|.   |.:....:.|::.:.|
  Fly  1554 ERIKDQAKALLRRVESIKSR-----RRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPP 1613

Mouse   731 EISALN-----------GNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTC 784
            ..|||:           ||.:.||     |.|::..:.:.||...|.   :||      ||:.|
  Fly  1614 SPSALSPMHTFPKAPFFGNDLKVP-----SHSDNFLSPNRSSPKRTP---TTP------RSMRT- 1663

Mouse   785 NKRVGMYLEGFDP--FSQSTLNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALSHGSFCPSG 847
                       .|  |..|.::.:.|....:..||..|                         |.
  Fly  1664 -----------SPLHFFSSPMSQLKEGKSDDSSSYYSD-------------------------SQ 1692

Mouse   848 NSSVNWRTGSFHGPGHLSLRRENSHDSPKELKRRNSSSSLSSRLSIYDNVPGSILYSSSGELADL 912
            .||    ||     |.||||:      |.:.:|                     ....:|
  Fly  1693 ESS----TG-----GKLSLRK------PSKARR---------------------FLQRTG----- 1716

Mouse   913 ENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPS 977
                   ::|||..|                          |.|.|....|.:..|.:.:.....
  Fly  1717 -------KVDDIGAH--------------------------SDSECHQGRKLLIKDANSNTTEVK 1748

Mouse   978 DLDST-GNSLNEPEEP---------------TDIPE-RRDSGVGASLTRCNRHR---LRWHSFQS 1022
            ....| |.|||..::|               |...| :.|.....:.|.....|   :||||||.
  Fly  1749 VKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQM 1813

Mouse  1023 SHRPSL---------------NSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWA 1072
            ..||::               ::..:.....|..|:.:::|.:|:.||..:|:|.||::.|::|.
  Fly  1814 EERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWE 1878

Mouse  1073 VPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRI 1137
            :|||:|:||:|||||:.||||||.:.:|||||.||.:::.|.|:|:.:.|||||:|||||.||||
  Fly  1879 LPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRI 1943

Mouse  1138 QALRQMNESAEDNVN----YEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRL 1198
            ..||:..|..:....    ::.|.|||||||||||||:|||.|:|.|:||||:.|:|::|.:.||
  Fly  1944 MKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRL 2008

Mouse  1199 QAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFH--LNTLKRE-NSS 1260
            .|::.|::||||||||:|..||.||:.|.|..::||||..||.||||.|:||  ::|.... ::|
  Fly  2009 DAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSAS 2073

Mouse  1261 PRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLF-QVPEEMSRCRNSYTEQELKPLTLEA 1324
            ||  ::.:..|.||.|:|.|..|:.:.|:.||...|::: ...|::|:|..||.| |.|||.|||
  Fly  2074 PR--RKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYME-ESKPLPLEA 2135

Mouse  1325 LGHLNSDQPADYRHFLQDCVDGLFKEVKEKFKGWVSYPT--SEQAELSYKKVSEGPPLRLWRSTI 1387
            ||  ...|..::|.:|.:|.....||.:||.:||.|..:  ....:::||||.:|.||||||.:.
  Fly  2136 LG--EGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCST 2198

Mouse  1388 EVPAAPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNL 1452
            |:...|:|:|:.::|::..||.:||..:.::.||.:||||||..:...   ..|:.|||:|:|:|
  Fly  2199 EIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDL 2260

Mouse  1453 PRGACALLLTSVDHDRA-PVAG-VRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYSKSF 1515
            |||||.::.||:||.:| |:.| ||..||.|||||||||||:|::.::.|.|::|..||||:|::
  Fly  2261 PRGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNY 2325

Mouse  1516 GHLCAAEVVKIRDSFSN--QNTESK 1538
            ||:|:..:.:||.:|.:  ...|||
  Fly  2326 GHICSHYLSRIRLAFKHVADGPESK 2350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlc1	NP_001181869.1	SAM_DLC1	468..527	CDD:188990	32/58 (55%)
		RhoGAP_DLC1	1087..1305	CDD:239840	109/225 (48%)
		SRPBCC	1330..1533	CDD:387369	88/208 (42%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	32/58 (55%)
		RhoGAP_DLC1	1893..2116	CDD:239840	108/224 (48%)
		SRPBCC	2148..2343	CDD:301327	86/197 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3058
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4702
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm42668
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	LDO	PTHR12659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.790