Protein Alignment PAX2 and ey

DIOPT Version :10

• Sequence 1: NP_003981.3
• Gene: PAX2 / 5076
• HGNCID: 8616
• Length: 432
• Species: Homo sapiens
• Sequence 2: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 183/597 - (30%)
• Similarity: 245/597 - (41%)
• Gaps: 209/597 - (35%)

Human    17 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPG 81
            |.||||||||||.||||||..||:||||||.|.|||||||.|:||:||||||||||||||||:|.
  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPR 162

Human    82 VIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRT----K 142
            .||||||:|||.:||.||::|||:.|::||||||||||.|.:|.||.:||||||||::|.    |
  Fly   163 AIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQK 227

Human   143 VQQPFHPTPDGAGTGVTAPGHTI----------------------------VPSTASPPVSS--- 176
            .||     ..|:|:..|:.|::|                            :..||:|..||
  Fly   228 EQQ-----STGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESG 287

Human   177 -ASNDPVGS-----YSINGILGIPRSNGE---KRKRDEVEVYTDPAHIRGGGGLH--LV------ 224
             |||...||     |....:|....:.|.   :..|....|...|.|: |....|  ||
  Fly   288 GASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHL-GTRSSHPQLVHGNHQA 351

Human   225 -----------------W---TLRDVSEGSVPN-------------------------------- 237
                             |   :|.::...|.||
  Fly   352 LQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQ 416

Human   238 ----------------------------GDSQSGVDS-------------LRKHLRAD--TFTQQ 259
                                        |::.:|..|             |::.|:.:  :||..
  Fly   417 RNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTND 481

Human   260 QLEALDRVFERPSYPDVFQASEHIKSEQG------------------------NEYSLPALTPGL 300
            |:::|::.|||..||||| |.|.:..:.|                        |:...|..| |.
  Fly   482 QIDSLEKEFERTHYPDVF-ARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNST-GA 544

Human   301 DEVKSSLSASTN--------PELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTST 357
            ....||.||:.:        ....|.:||:...|.|       :|:.|...  |.|...:....|
  Fly   545 SATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSV-------STINGLSS--PSTLSTNVNAPT 600

Human   358 LAGMVPGSEFSGNPYSH--PQYTAYNEAWRFSNPALLMPPPGAPPLPLLPLPMTATSYRG-DHIK 419
            |...:..|| |..|..|  |..|:.|:..|.|.....:         ..|.|:....::. .||:
  Fly   601 LGAGIDSSE-SPTPIPHIRPSCTSDNDNGRQSEDCRRV---------CSPCPLGVGGHQNTHHIQ 655

Human   420 LQADSFGLHIVP 431
            ....:.|..:||
  Fly   656 SNGHAQGHALVP 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX2	NP_003981.3	PAX	16..140	CDD:128645	92/122 (75%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		46/55 (84%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		31/51 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..325		7/28 (25%)
		Pax2_C	305..>390	CDD:463563	25/94 (27%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	92/122 (75%)
		Homeodomain	473..528	CDD:459649	15/55 (27%)