Protein Alignment PAX2 and Poxm

DIOPT Version :9

• Sequence 1: NP_003981.3
• Gene: PAX2 / 5076
• HGNCID: 8616
• Length: 432
• Species: Homo sapiens
• Sequence 2: NP_001036687.1
• Gene: Poxm / 40990
• FlyBaseID: FBgn0003129
• Length: 370
• Species: Drosophila melanogaster
• Alignment Length: 415
• Identity: 150/415 - (36%)
• Similarity: 190/415 - (45%)
• Gaps: 102/415 - (24%)

Human     8 DPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRY 72
            ||.|.. |.:|.|||||||||||||||:..|.||||||..|:||||||||||||||||||||.||
  Fly     2 DPESQC-PQYGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARY 65

Human    73 YETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINR 137
            :|||||.||.||||||:|.|||||:.|.|.|:::|.:||||||||||:|||||...|||||||:|
  Fly    66 HETGSILPGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISR 130

Human   138 IIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRK 202
            |:|.|               :.:.||...|.|.   :.|.|:...||.|.||    .::||....
  Fly   131 ILRNK---------------LGSLGHQHTPGTV---MGSGSSSGGGSVSSNG----GQNNGTSAS 173

Human   203 RD-EVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVP---NGDSQSGVDSLRKHLRADTFTQQQLEA 263
            .: .:....:|    |||..|             |   :....:...:...|:.|.......|
  Fly   174 NNINLSNLGNP----GGGPHH-------------PHHHHHHQSAAAAASAHHVHAHAHAHAHL-- 219

Human   264 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPAL----TPGLDEVKSSLSASTNPELGSNVSGTQT 324
                     |..::|           .||..|.    ||         ..|.:|..|:...|:
  Fly   220 ---------YNSIYQ-----------PYSAAAAYSMKTP---------CGSPSPPQGAGGQGS-- 253

Human   325 YPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNP 389
                             .||  |....|...:..|...|.|....:..:|.|..|...:.:....
  Fly   254 -----------------VPH--PHQLRSVAAAAAAAHWPSSHSVSDILAHHQAVALRASCQVGVG 299

Human   390 ALLMPPPGA--PPLPLLPLPMTATS 412
            ...|...|:  .|||:.|.|:..|:
  Fly   300 VGGMGGMGSTVSPLPMTPSPVAGTA 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX2	NP_003981.3	PAX	16..140	CDD:128645	93/123 (76%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		32/47 (68%)
		homeodomain	255..>278	CDD:412151	2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..325		4/20 (20%)
		Pax2_C	305..>390	CDD:403565	14/84 (17%)
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	93/122 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910